iron overload is a clinical problem which can be prevented by using iron chelating agents. an alternative method of relieving iron overload is to reduce iron absorption from the intestine by administering specific iron chelating agents, which can bind iron to form nonabsorbable complexes. based on this strategy, a series of polymeric ligands containing the chelating moiety 3-hydroxypyridin-4-on...

Starting from 2-imino-N-phenyl-2H-chromene-3-carbox-amide, (1) a series of functionalized chromenes were achieved; such as, 2-ethoxy-2,3-dihydro-3-phenylchromeno[2,3-d]pyrimidin-4-one (2), and 2-hydrazinyl-2,3-dihydro-3-phenylchromeno-[2,3-d]pyrimidin-4-one (3). Furthermore, reactions of (3) with some of laboratory available compounds gave pyrazoles (4 9, 12, 13a, 13b), tetrazoles (11), 2-(2-be...

In(OTf)3-catalyzed robust and sustainable one-pot access to previously unknown and synthetically demanding polysubstituted pyrroles via [3 + 2] annulation of α-oxoketene-N,S-acetals with β-nitrostyrenes has been achieved under solvent-free conditions. The merit of this domino Michael addition/cyclization sequence is highlighted by its operational simplicity, short reaction time (5-10 min), good...

Twenty-five polysubstituted phthalazinone derivatives were synthesized and tested for their antifungal activity against a panel of pathogenic and clinically important yeasts and filamentous fungi. Among them, the compound 4-(4-chlorobenzyl)-2-methylphthalazin-1(2H)-one (5) exhibited a remarkable antifungal activity against standardised strains of dermatophytes and Cryptococcus neoformans, as we...

al-mcm-41 nanoreactors is found to be a remarkable efficient catalyst for one-pot multicomponent cyclocondensation of benzil, aniline or ammonium acetate and aromatic aldehydes for the synthesis of polysubstituted imidazoles under solvent-free conditions. the reaction was efficiently promoted by 10 mg nano-al-mcm-41 and the heterogeneous catalyst was recycled for four runs in this reaction with...

In the title mol-ecule, C(10)H(12)N(2)O, the dihedral angle between the benzene and imidazole rings is 14.86 (16)°. The approximately planar arrangement of the mol-ecule results in a distance of 2.54 Å between an ortho-H atom of the benzene ring and the double-bonded N atom of the imidazole ring. In the crystal structure, symmetry-related mol-ecules are linked by inter-molecular N-H⋯N hydrogen ...

In the mol-ecule of the title compound, C(10)H(12)N(2), the six- and five-membered rings are almost co-planar, forming a dihedral angle of 3.56 (8)°. In the crystal structure, neighbouring mol-ecules are linked together by inter-molecular N-H⋯N hydrogen bonds into one-dimensional infinite chains along the c axis. The crystal structure, is further stabilized by weak inter-molecular C-H⋯π and π-π...

( )-Cryptocaryalactone (6-[2-acetoxY-4-phenyl-3-butenyl}5,6-dihydro-2-pyranone) and ()-deacetylcryptocaryalactone (6-[2-hydroxy-4-phenyl-3-butenyIJ-5,6-dihydro-2-pyranone) isolated from Cryptocarya moschata seeds are natural germination inhibitors. Applied at 0.004 M, the second compound completely arrested germination of velvetleaf (Abulilolllheophrasli) and decreased the germination rate of s...