نتایج جستجو برای: polyribosyl ribitol phosphate prp
تعداد نتایج: 110328 فیلتر نتایج به سال:
Platelet-rich plasma (PRP) is a solution derived from whole blood that is enriched in the platelet fraction. Platelets serve as a reservoir of growth factors and cytokines. When platelets are activated in vivo, signaling molecules are released into the immediate microenvironment and activate receptors for various pathways. PRP has been applied to bedsores to promote healing. Over the last decad...
BACKGROUND Cartilage tissue has limited regenerative capacity and the management of cartilage defects has always been a challenging issue. Platelet-rich plasma (PRP) has been recently been used to improve healing of cartilage defects. In the present experiment, we aimed to investigate the effects of PRP on regeneration capacity as well as survival of the cartilage grafts in a rabbit model. M...
The hallmark of transmissible spongiform encephalopathies (TSEs or prion diseases) is the accumulation of an abnormally folded, partially protease-resistant form (PrP-res) of the normal protease-sensitive prion protein (PrP-sen). PrP-sen is attached to the cell membrane by a glycosylphosphatidylinositol (GPI) anchor. In vitro, the anchor and the local membrane environment are important for the ...
In Vivo Generation of Neurotoxic Prion Protein: Role for Hsp70 in Accumulation of Misfolded Isoforms
Prion diseases are incurable neurodegenerative disorders in which the normal cellular prion protein (PrP(C)) converts into a misfolded isoform (PrP(Sc)) with unique biochemical and structural properties that correlate with disease. In humans, prion disorders, such as Creutzfeldt-Jakob disease, present typically with a sporadic origin, where unknown mechanisms lead to the spontaneous misfolding ...
Abstract Background Non-healing surgical wounds is a risk in certain patients. Recently, allogenic plasma-rich-platelet (PRP) used such as regenerative treatment of different non-healing wounds. Purpose We explore the potential role using platelet-derived growth factors from single donor PRP, with freeze-thaw process, for scar ulcer. Methods have PRP preparation protocol that involved cycle cen...
مقدمه آسیب لایه فیبر عصبی شبکیه (RNFL) به عنوان عارضه احتمالی فوتوکوآگولاسیون پان رتینال (PRP) مطرح گردیده است. رنگ پریدگی دیسک اپتیک یافته ای شایع در بیماران دیابتی است ولی تا کنون ارتباط آن با PRP در یک مطالعه کنترل شده ثابت نشده است. لذا هنوز مشخص نیست که این یافته نتیجه روند دیابت است یا PRP در آن نقش دارد. مطالعه حاضر برای بررسی اثر PRP بر ضخامت RNFL به عنوان یک شاخص غیر مستقیم از آسیب ...
The pattern of scrapie prion protein (PrP(Sc)) accumulation in the brain is different for each prion strain. We tested whether the PrP(Sc) deposition pattern is influenced by the Asn-linked oligosaccharides of PrP(C) in transgenic mice. Deletion of the first oligosaccharide altered PrP(C) trafficking and prevented infection with two prion strains. Deletion of the second did not alter PrP(C) tra...
Objective(s): Platelet-rich plasma (PRP) has recently emerged as a promising strategy in regenerative medicine due to its multiple endogenous growth factors. Little is known about the role of PRP as a promoter in chondrogenesis of human adipose derived stem cells (hADSCs). The aim of this study was to determine whether PRP may be considered as a natural and easy achievable source o...
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