normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background : there is a lack of data on familial aggregation of colorectal cancer (crc) in iran. we aimed to determine the frequency of hereditary nonpolyposis colorectal cancer (hnpcc) and familial colorectal cancer (fcc) and to determine the frequency of extracolonic cancers in these families in isfahan. methods : we rev...

Aim. To improve the results of surgical treatment for patients with non-neoplastic colonic diseases by optimizing choice radical surgery extent. Materials and methods. The study material was analysis interventions performed in 87 diseases: ulcerative colitis, Crohn’s disease, familial adenomatous polyposis, chronic coloproctogenic stasis, diverticular colon disease. age operated 20–72 years. Th...

  Background and Objectives: Nasal polyposis is a diseases resulting from complex pathogenetic mechanisms. Some studies showed that TGFβ1 had significant role in this pathogenesis. In this study, we investigated the roe of cytokines and mediators in polyp development. Material and Methods: In this case- control study, healthy nasal mucosal samples were obtained from 24 peopl...

gardner's syndrome is an autosomal dominant inherited disorder. familial polyposis of the colon, osteomas, hypertrophy of the retinal-pigmented layer and a multitude of soft tissue tumors are characteristic features. the syndrome may be presented with colonic or extracolonic symptoms. a 75-year-old male patient presented to al-zahra clinic with diffuse abdominal pain. an abdominal surgery was p...

conclusions the patients with diffuse pjs may be asymptomatic and without gastrointestinal or extragastrointestinal malignancies. introduction peutz-jeghers syndrome (pjs) is a rare disorder characterized by mucocutaneous perioral pigmentation, gastrointestinal hamartomatous polyposis, and an increased risk of malignancy. families with pjs may show a variable spectrum of manifestations in spite...

Familial adenomatous polyposis (FAP), caused by a germline mutation in the adenomatous polyposis coli (APC) gene on chromosome 5q21, is an autosomal dominant disorder characterized by hundreds to thousands of adenomas throughout the gastrointestinal tract. A variety of extraintestinal manifestations, including thyroid, soft tissue, and brain tumors, may also be present. These patients inevitabl...

Cronkhite-Canada syndrome is a rare disease characterised by diffuse polyposis of the gastrointestinal tract, diarrhoea, weight loss, abdominal pain, cutaneous hyperpigmentation, dystrophic changes of fingernails, and alopecia. The etiology is probably autoimmune and diagnosis is based on history, physical examination, endoscopic findings of gastrointestinal polyposis, and histology. The diseas...

Regulatory T cells (Tregs) that expand in human colon cancer express retinoid-related orphan receptor γt (RORγt) and exert potent T-cell suppressive functions while mediating pro-inflammatory effects. Similar Tregs expand and drive a vicious cycle of inflammation in murine polyposis. Targeting RORγt in Tregs interrupts such a cycle and protects mice against polyposis, suggesting that a similar ...