نتایج جستجو برای: polyostotic fibrous dysplasia
تعداد نتایج: 55033 فیلتر نتایج به سال:
Fibrous dysplasia was first described by Lichtenstein in 1938 as a disorder characterized by progressive replacement of normal bone elements by fibrous tissue. It is a bone tumor that, although benign, has the potential to cause significant cosmetic and functional disturbance, particularly in the craniofacial skeleton. Its management poses significant challenges to the surgeon. Its compression ...
Intravenous infusions with the bisphosphonate compound pamidronate decrease bone pain and reportedly can lead to refilling of dysplastic lesions in adults with fibrous dysplasia (FD) of bone. Here we describe the effects of this treatment approach in 18 children and adolescents (age at start of therapy, 6.2-17.5 yr; eight girls) with polyostotic FD, who received pamidronate for 1.2-9.1 yr (medi...
McCune-Albright syndrome (MAS) is characterized by the triad of precocious puberty, café au lait pigmentation, and polyostotic fibrous dysplasia (FD) of bone, and is caused by post-zygotic somatic mutations-R201H or R201C-in the guanine nucleotide binding protein, alpha stimulating (GNAS) gene. In the present study, a novel peptide nucleic acid (PNA) probe with fluorescent labeling was designed...
Malignant transformation in fibrous dysplasia (FD) is a rare event, reported to occur in approximately less than 1% of cases. The most common type of secondary malignant tumor arising from FD is osteosarcoma. We report a case of secondary chondrosarcoma arising in a patient with polyostotic FD. Magnetic resonance imaging (MRI) showed a multilobulated tumor, 12.6 cm in diameter, in the right sca...
Fibro-Osseous lesions are numerous and heterogeneous group of tumors of the jaws which pose difficulties on classification, diagnosis and treatment. The present study was undertaken to evaluate fibrous dysplasia and the diagnostic value of histologic examination for its workup. Fifteen patients with cranio-facial bone lesion, who had previous pathologic diagnosis of fibrous dysplasia, were ...
Fibrous dysplasia (FD) of bone is a rare skeletal disease often associated with bone pain, deformities and fractures. The bisphosphonate therapies are reported to be useful for bone pain, but seem to be not suitable for fracture repairs of extremities. This is the first report of zoledronate-induced radiological improvement and long bone fracture union in polyostotic FD. A 30-year-old Japanese ...
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