BACKGROUND Reactive oxygen species can attack and damage almost every molecule found in living cells, including proteins, carbohydrates, lipids, and DNA. For this reason, their production is normally tightly controlled. Among the most important defenses against these radicals are the superoxide dismutase (SOD) enzymes and catalase (CAT). Increasing attention has been given to the role of reacti...

acetyl-coenzyme a carboxylase α (acc-alpha) is considered as the key regulatory enzyme in fatty acid biosynthesis. acc-alpha gene is located on caprine chromosome 11 and is polymorphic in many goat breeds. in the current study, we aimed to find possible single nucleotide polymorphisms (snps) in the exon 1 region of the acc-alpha gene in iranian mahabadi goat breed. genomic dna was extracted fro...

coronary artery disease (cad) is the leading cause of mortality in many parts of the world. genome-wide association studies (gwas) have identified several genetic variants associated with cad in low-density lipoprotein receptor (ldlr) locus. this study was evaluated the possible association of genetic markers at ldlr locus with cad irrespective to lipid profile and as well as the association of...

conclusions the results indicated that there was a positive association between susceptibility to chronic hbv infection and tnf-α polymorphism. in addition, hbv patients carrying -308 gg, -857 cc, and -863 aa genotypes with lower serum levels of tnf-α had an increased risk of infection. background the host genetic background regulates the natural history of chronic hepatitis b virus (hbv) infec...

background: the osteopontin (opn) is a highly phosphorylated glycoprotein in numbers of bovine tissues and milk. opn has been reported to be associated with milk production in cattle.objective: the genotype and allelic frequencies for opn and its association with milk production will be evaluated in iranian holstein bulls.  materials and methods: bulls dna (100) was isolated. oligo was used for...

background: numerous studies have evaluated the association between the angiotensinogen (agt) t174m polymorphism and ischemic stroke(is) risk. however, the specific association is still controversial. materials and methods: in order to explore this association more deeply, we performed a meta-analysis. all of the relevant studies were identified from pubmed, embase, and chinese national knowled...

background autism spectrum disorder (asd) is a intricate childhood neuropsychiatric disorder that is described by deficits in communication of verbal and non-verbal, reciprocal social interactions, stereotypic behaviors, interests, and activities. the studies of post-mortem neuro-anatomical anomalies have indicated that migration alterations could occur early during development (first trimester...

there are much heterogeneity in the genetic variation of type 2 diabetes (t2d). the purpose of this study was to investigate the association of seven novel genetic loci identified in a recent genome-wide association studies (gwas) with t2d in chinese dong populations.a case-controlled study was performed in individuals of chinese dong nationality. the genotypes of pard3b (rs849230), loc729993 (...