نتایج جستجو برای: polygenic dyslipidemia
تعداد نتایج: 16254 فیلتر نتایج به سال:
Cardiovascular disease (CVD) is a significant cause of illness, disability, and death among individuals with diabetes. The macrovascular complications of diabetes— Coronary Heart Disease (CHD), Cerebro Vascular Accidents (CVA), and Peripheral Vascular Disease (PVD)— all being different facets of the same vascular damage – account for more than 70% of all deaths in individuals with diabetes. CVD...
The American Psychiatric Association estimates that 3 to 7 per cent of all school aged children are diagnosed with attention deficit hyperactivity disorder (ADHD). Even after correcting for general cognitive ability, numerous studies report a negative association between ADHD and educational achievement. With polygenic scores we examined whether genetic variants that have a positive influence o...
A method was derived to estimate effects of quantitative trait loci (QTL) using incomplete genotype information in large outbreeding populations with complex pedigrees. The method accounts for background genes by estimating polygenic effects. The basic equations used are very similar to the usual linear mixed model equations for polygenic models, and segregation analysis was used to estimate th...
Major psychiatric disorders, including attention deficit hyperactivity disorder (ADHD), autism (AUT), bipolar disorder (BD), major depressive disorder (MDD), and schizophrenia (SZ), are highly heritable and polygenic. Evidence suggests that these five disorders have both shared and distinct genetic risks and neural connectivity abnormalities. To measure aggregate genetic risks, the polygenic ri...
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