Spontaneous forms of the ovarian hyperstimulation syndrome (sOHSS) are nearly always reported between 8 and 14 weeks of pregnancy and also with follicle-stimulating hormone (FSH) producing pituitary adenoma. The syndrome has been previously reported in rare instances of increased production of human chorionic gonadotrophin (hCG) such as multiple pregnancies, hydatiforme mole, polycystic ovary d...

Background Among the infertility disorders, polycystic ovary syndrome (PCOS) is one of the most common, affecting approximately 4 million women in the U.S. and more than 100 million women worldwide.1 PCOS is characterized by both reproductive and metabolic dysfunctions with familial clustering.2 From a reproductive perspective, PCOS is a heterogeneous syndrome characterized by hyperandrogenism ...

OBJECTIVES We aimed to investigate whether glucocorticoid receptor gene polymorphisms are associated with clinical and metabolic profiles in patients with polycystic ovary syndrome. Polycystic ovary syndrome is a complex endocrine disease that affects 5-8% of women and may be associated with metabolic syndrome, which is a risk factor for cardiovascular disease. Cortisol action and dysregulation...

OBJECTIVE To compare lipid profile in lean and obese women with polycystic ovary syndrome with normal weight and obese controls. METHOD The case-control study was conducted at the Department of Chemical Pathology, Liaquat National Hospital, Karachi, from March 2006 to April 2007. It comprised 50 cases of polycystic ovary syndrome along with 50 healthy controls matching for age, gender and wei...

BACKGROUND Metformin is effective for the treatment of polycystic ovary syndrome, but conflicting results regarding its effect on adipocytokine levels (adiponectin, resistin, visfatin, and leptin) in patients with polycystic ovary syndrome receiving metformin treatment have been reported. To provide high-quality evidence about the effect of metformin treatment on adipocytokines in patients with...

Due to genetic heterogeneity and variable diagnostic criteria, genetic studies of polycystic ovary syndrome are particularly challenging. Furthermore, lack of sufficiently large cohorts limits the identification of susceptibility genes contributing to polycystic ovary syndrome. Here, we carried out a systematic search of studies deposited in the Gene Expression Omnibus database through August 3...

The polycystic ovary syndrome was diagnosed according to the following criteria: [1] bilateral polycystic ovaries on ultrasonography; [2] oligomenorrhea or amenorrhea, hirsutism, obesity, or chronic anovulation, or any combination of these conditions; [3] hyperandrogenemia (elevated serum levels of testosterone, free testosterone, or androstenedione); [4] elevated serum LH levels; and [5] exclu...

Ovarian hyperstimulation syndrome (OHSS) is a serious and potentially life-threatening complication of ovulation induction. The syndrome almost always presents either after hCG administration in susceptible patients or during early pregnancy. Despite many years of clinical experience, the pathophysiology is poorly understood and there is no reliable test to predict patients who will subsequentl...

background: polycystic ovary syndrome (pcos) is the most common chronic endocrine disorder. it has significant and diverse clinical consequences including reproductive, metabolic, and psychological morbidities as well as predisposition to malignancies. it is unclear how women with pcos experience symptoms of this syndrome. objectives: the aim of this study was to clarify the dimensions and comp...