Our laboratory has developed optimized and uniform methods for the isolation and culture of normal mammary epithelial cells from both rats and humans. We have reported that, in a cell-mediated mutagenesis assay, treatment of rat mammary epithelial cells with 7,12-dimethylbenz(a)anthracene, but not benzo(a)pyrene, resulted in significant rates of mutagenesis in cocultured V-79 cells. An opposite...

A mild and facile two-step access towards complex, polycyclic dibenzothiazepine derivatives via multicomponent reaction chemistry is demonstrated. The peculiar butterfly conformation observed studied.

Molecular dosimetry for polycyclic aromatic hydrocarbon-DNA adducts, genetic predisposition to cancer, and their interrelationships are under study in numerous laboratories. This report describes a modified 32P-postlabeling assay for the detection of polycyclic aromatic hydrocarbon-DNA adducts that uses immunoaffinity chromatography to enhance chemical specificity and quantitative reliability. ...

The Milnor-Wolf Theorem characterizes the finitely generated solvable groups which have exponential growth; a finitely generated solvable group has exponential growth iff it is not virtually nilpotent. Wolf showed that a finitely generated nilpotent by finite group has polynomial growth; then extended this by proving that polycyclic groups which are not virtually nilpotent have expontial growth...

33 polycyclic derivatives have been studied and tested on Leishmania donovani and L. major promastigotes. Their antileishmanial activity was assessed in vitro and an assay of their cytotoxicity was realized on human myelomonocytic cell line. The reference molecules used in the assays were amphotericin B and pentamidine. Among the compounds tested, 29 possess an antileishmanial activity; 25 of t...

In previously reported experiments, the car cinogenic potency for mice of extracts of processed rubber was traced to the presence of 3,4-benz pyrene and related compounds (13). A search for the origin of these hydrocarbons was next under taken. Samples of crude rubber, both natural and synthetic, did not contain any of these hydrocar bons when they were sought by extraction, chro matography, an...

Context. This is the fourth in a series of papers based on the ISOCAM Parallel Survey at 6.7 μm. While the first three papers have been devoted to active galactic nuclei (AGN), here we report on emission-line galaxies without AGN signatures in their optical spectra. Aims. Polycyclic aromatic hydrocarbon (PAH) emission has been found in both starbursts and modestly starforming galaxies, but the ...

Polycyclic aromatic hydrocarbons are organic compounds with highly toxic, carcinogenic, and mutagenic properties, which adversely affect the basic biological parameters of the soil, including the count of microorganisms, and the enzymatic activity. In addition to disturbances to the biological activity of the soil, PAHs may also exhibit toxic effects on plants. In view of the above, the study i...