We have studied experimentally within the pH range of 3.65-5.5 at 50 degrees C the hydrolysis of cellobiose with Novozym 188, a commercial product with high beta-1,4-glucosidase activity derived from Aspergillus niger. We used wide variations in the conversion to be able to apply the integral method and thus determine that there is substrate and mixed product inhibition. Whether the SES triple ...

We studied the antiadhesive effect of Poloxamer 407 (P407), together with modifications in the antimicrobial susceptibility of residual adherent staphylococci. Bacterial adherence was markedly inhibited (77% to more than 99.9%) whether polymethylmethacrylate was exposed to P407 before or during the adherence assay. Furthermore, residual adherent staphylococci appeared to be more susceptible to ...

Etravirine is an antiviral belonging to biopharmaceutics classification system class IV due low aqueous solubility and poor permeability. In this study, augment the dissolution profile of etravirine, solid lipid nanoparticles have been formulated by utilizing mixture Compritol® 888 ATO Gelucire® 50/13 as lipids poloxamer 188 surfactant hot homogenization technique. Effect variables, ratio lipid...

The aim of this study was to understand the effect high shear homogenization (HSH) and ultrasonication (US) on physicochemical properties blank olanzapine loaded nanostructured lipid carriers (NLCs) along with their drug loading potential release profiles from formulated particles. NLCs were prepared different ratios Compritol Miglyol as solid liquid lipids, respectively, under changing HSH US ...

PURPOSE Atherosclerosis is characterized by the progressive deposition of lipids and inflammatory process. We attempted to develop a chemically-induced hyperlipidemic mice model, using poloxamer-407 and evaluated the lipid lowering and anti-inflammatory effect of P. notoginseng compared with that of atorvastatin, an antihyperlipidemic drug. MATERIALS AND METHODS Male Wistar rats were randomly...

Lack of mucoadhesive properties is the major drawback to poloxamer 407 (F127)-based in situ hydrogels for mucosal administration. The objective of the present study was to construct a novel mucoadhesive and thermosensitive in situ hydrogel drug delivery system based on an amino-functionalized poloxamer for vaginal administration. First, amino-functionalized poloxamer 407 (F127-NH2) was synthesi...

The purpose of this study is to develop and characterize the nature of a solid dispersion system of nifedipine in a polymer matrix consisting of PVP K30 and poloxamer 407. Dispersions consist of drug, polymeric carrier and surfactant carrier. Binary solid dispersions consisting of nifedipine and PVP K30 were developed by solvent evaporation method. Poloxamer 407, surfactant carrier was incorpor...

In this study, we examined and compared two different lipid-based nanosystems (LBNs), namely Transferosomes (TFs) Monoolein Aqueous Dispersions (MADs), as delivery systems for the topical application of Ferulic Acid (FA), an antioxidant molecule derived from natural sources. Our results, demonstrated through Franz-cell experiments, indicate that LBNs produced with poloxamer 188 in their composi...

The purpose of this study was to investigate the loading properties non-psychoactive cannabidiol (CBD) in a new nanostructured lipid carrier (NLC), evaluating its bioaccessibility gastric and intestinal simulated physiological media. CBD has low water solubility, as well high instability conditions acidic media, which results very bioavailability—less than 6%. NLCs containing (10 mg/mL), Compri...

To determine the efficacy of single and multiple administrations Poloxamer 188 (P188) in saving meniscal cells following an injurious impact. Meniscal explants were harvested from both lateral medial menisci Flemish Giant rabbits. After a 24-h incubation period, subjected to 50% impact strain simulate traumatic joint injury, then placed media with or without supplemented P188. Temporal P188 ove...