BACKGROUND Avoidance behavior against positive allergens detected by using multiple allergen simultaneous test (MAST)-immunoblot assay in patients with urticaria has been rarely reported. OBJECTIVE We aimed to assess the avoidance behavior of patients with urticaria against positive allergens detected with a MAST. METHODS One hundred and one urticaria patients who showed positivity to at le...

INTRODUCTION The role of monokine induced by interferon-γ (IFN-γ, MIG/CXCL9), IFN-γ-inducible protein (IP-10/CXCL10), and IFN-inducible T cell α chemoattractant (I-TAC/CXCL11) in allergic inflammation has not been explored in detail in vivo. The aim of the study was to examine the changes in concentrations of MIG/CXCL9, IP-10/CXCL10 and I-TAC/CXCL11 in nasal lavages collected from healthy and a...

Abstract Pollen allergies are responsible for a considerable global public health burden, and understanding exposure is critical to addressing the impacts. Atmospheric pollen counts routinely used as predictor of risk; however, immune responses triggered by specific proteins known allergens, which occur both within on surface grain. The ratio between atmospheric allergen concentrations (‘pollen...

Background Food allergy may be life-threatening and affected individuals have impairment in quality of life. Children with multiple and severe food allergies usually have other allergic manifestations like allergy to furry animals and pollen, causing eczema and asthma. Treatment with the anti-IgE (omalizumab) is indicated for severe allergic asthma. Oral immunotherapy (OIT) has been performed i...

Methods Twenty-nine patients with seasonal SAR (positive SPT to grass and/or olive pollen) with well-defined symptoms during pollen season in addition to nasal symptoms throughout the year were included. Clinical questionnaires, skin tests, serum specific IgE, nasal levels of tryptase and eosinophil cationic protein, and nasal allergen provocation test (NAPT) with grass, olive, D. pteronyssinus...

Background Allergen-specific immunotherapy (SIT) is the only specific, disease-modifying treatment for allergy and may have long-lasting effects. It is given traditionally in the form of multiple subcutaneous injections which makes the treatment inconvenient. Furthermore, systemic allergenadministration may cause severe side effects. Therefor the development of alternative routes for SIT has be...

Background Determining the content of individual allergens at isoform level has become important for comprehensive standardization and quality control of allergen products as the content of individual allergens has an impact on the potency of allergen extracts. Mass spectrometry (MS) is a dominant and indispensable proteomic tool that has been employed for allergen analysis. Therefore, the main...

There is increasing evidence that environmental inhalatory aller­ gens are not exclusively carried in the atmosphere by so-called primary allergen carriers, such as mite faecal balls, pollen grains, etc., of relatively big aerodynamic sizes, but also by secondary allergen carriers, mostly of (much) smaller dimensions. This evidence is illustrated by three exam­ ples of common environmental alle...

Four allergenic proteins of Bahia (BA) grass pollen with estimated molecular weights of 45, 33, 31 and 28 kD were previously detected. Although all four proteins were reactive with BA grass allergic patient sera, the 33kD component was previously verified as a major allergen. The investigators report here for the first time, the similarities between the group I 33 kD allergen of BA grass, Pas n...

Background The aim of this non-interventional study was to document the impact of a sublingual allergen immunotherapy (AIT) with Oralair 5-grass pollen tablets (Stallergenes, France) on symptom severity (rhinitis, conjunctivitis, asthma), use of symptomatic medication and tolerability in patients with grass pollen-induced allergic rhinoconjunctivitis (RC) over 2 years of routine medical practic...