Background: Phosphodiesterases (PDEs) play a major role in the regulation of cyclic adenosine monophosphate (cAMP)- and cyclic guanosine monophosphate (cGMP)-mediated pathways. Their inhibitors exhibit anti-inflammatory, vasodilatory and antithrombotic effects. Therefore, consumption of foods with PDE-inhibiting potential may possess beneficial influence on the risk of cardiovascular diseases. ...

Essential differences in the degree of papaverine [5 x 10(-5) M]- and theophylline [1 x 10(-3) M]-induced inhibition of cyclic nucleotide phosphodiesterase (PDE) were found in homogenates from different structures of the CNS as well as from different organs of male albino rats. Both inhibitors of PDE showed a mosaic pattern of their inhibitory effects on the enzyme activity of the brain structu...

The possible involvement of phosphodiesterase (PDE) activation in phototransduction was investigated in gecko photoreceptors by comparing the in situ PDE activity with the photoreceptor potential. In the dark, intracellular injection of cGMP into a gecko photoreceptor caused a long-lasting depolarization. An intense light flash given during the depolarization phase repolarized the cell with a s...

BACKGROUND The anti-inflammatory effects of the selective phosphodiesterase (PDE) inhibitors cilostazol (PDE 3), RO 20-1724 (PDE 4) and sildenafil (PDE 5) were examined in a murine model of allergic asthma. These compounds were used alone and in combination to determine any potential synergism, with dexamethasone included as a positive control. METHODS Control and ovalbumin sensitised Balb/C ...

In the remainder, we call such a variety a convex symplectic variety. A convex symplectic variety has been studied in [K-V], [Ka 1] and [G-K]. One of main difficulties we meet is the fact that tangent objects TX and T 1 Y are not finite dimensional, since Y may possibly have non-isolated singularities; hence the usual deformation theory does not work well. Instead, in [K-V], [G-K], they introdu...

In the remainder, we call such a variety a convex symplectic variety. A convex symplectic variety has been studied in [K-V], [Ka 1] and [G-K]. One of main difficulties we meet is the fact that tangent objects TX and T 1 Y are not finite dimensional, since Y may possibly have non-isolated singularities; hence the usual deformation theory does not work well. Instead, in [K-V], [G-K], they introdu...

Stein's method is used to prove approximations in total variation to the distributions of integer valued random variables by (possibly signed) compound Poisson measures. For sums of independent random variables, the results obtained are very explicit, and improve upon earlier work of Kruopis (1983) and Cekanavicius (1997); coupling methods are used to derive concrete expressions for the error b...

I study large-eddy simulation of the atmospheric boundary layer on block structured non-uniform grids. This type of grid, which includes nested grids, is very popular in atmospheric science as a way of concentrating computational power. Large-eddy simulation is a widely used method of approximately solving incompressible Navier-Stokes in turbulent regimes, including the atmospheric boundary lay...

In the remainder, we call such a variety a convex symplectic variety. A convex symplectic variety has been studied in [K-V], [Ka 1] and [G-K]. One of main difficulties we meet is the fact that tangent objects TX and T 1 Y are not finite dimensional, since Y may possibly have non-isolated singularities; hence the usual deformation theory does not work well. Instead, in [K-V], [G-K], they introdu...