Content production processes currently experience a shift in focus. Due to the growing trend of highly individualized learning scenarios they have to face and to combine a multitude of different standards. The European eContent+ network of Excellence ICOPER researches possible strategies and implementations to deal with this new situation. In its course the project develops a comprehensive set ...

This paper presents a methodological model for the establishment of Open Access to scientific information at Embrapa, as a strategy for scientific information and knowledge management. The model consists of elements that speed up scientific communication processes and allow for the research output management. The aim is to provide the necessary mechanisms to capture, store, organize, preserve a...

Mid-frequency instability (MFI) generally limits the application of step motors with constant-voltage drive to a speed range well below theoretical limit imposed by inductance, back EMF, and friction torque. Analytical studies MFI in specific motor types configurations have been reported literature, each focused on particular method analysis. The goal this paper is develop single model structur...

We are investigating the biological and biomedical imaging roles and impacts of fluorescent metallocorrole-TiO2 nanoconjugates as potential near-infrared optical contrast agents in vitro in cancer and normal cell lines. The TiO2 nanoconjugate labeled with the small molecule 2,17-bis(chlorosulfonyl)-5,10,15-tris(pentafluorophenyl)corrolato aluminum(III) (1-Al-TiO2) was prepared. The nanoparticle...

The toxic mechanisms of cisplatin have been frequently studied in many species and in vitro cell models. The Netherlands Toxicogenomics Centre focuses on developing in vitro alternatives using genomics technologies for animal-based assays on, e.g. genotoxic hazards. Models such as human hepatocellular carcinoma cell line (HepG2) cells, mouse primary hepatocytes (PMH) and mouse embryonic stem ce...

Estrogen production and metabolism play critical roles in the development and pathogenesis of endometrial carcinoma. Cytochrome P450 1B1 (CYP1B1) and catechol-O-methyltransferase (COMT) are two key enzymes in the estrogen metabolism pathway that result in the hydroxylation and conjugation of estradiol, respectively. We evaluated the association between the CYP1B1 Leu432Val and CYP1B1 Asn453Ser ...

One of the biggest obstacles for information dissemination to a user community is that many Digital Libraries (DL) or bibliographic databases use heterogeneous technologies that inhibit interoperability. The Open Archives Initiative (OAI) addresses interoperability by using a framework to facilitate the discovery of content stored in distributed archives or bibliographic databases through the u...