Stress can enhance and inhibit nociception depending on the situation. Thus, simply shifting the context from the elevated plus maze (EPM) which has been shown to produce stress-induced antinociception to a different environment could produce drastic and rapid changes in nociception. The present experiment tested this hypothesis by assessing nociception in rats and mice during and immediately a...

Blackberry leaves (Morus nigra) are used in menopause to relieve hot flashes and night sweats have been investigated metabolic disorders. However, few studies its effects on behavioral disorders when associated with menopause. This study evaluated the of a hydroalcoholic extract M. nigra (MN) body composition, glucose tolerance, depression anxiety-like behaviors ovariectomized rats. For this pu...

Previous studies indicated that Foeniculum vulgare (FV) as a folk remedy plant that overgrows in the different parts of Iran and suggested that have antinociceptive activity and sedative. In this study, we investigated of anxiolytic effects in different doses of the extracts of FV. In this study, fourty male mice (25-30 gr) were used in elevated plus maze model. Different doses of the extract o...

Portulaca oleracea (PO) overgrows in the different parts of Iran. In previous studies, ethanolic extracts of PO showed antinociceptive activity, sedative in animal. This study was designed to evaluate anxiolytic effects in different doses of the aqueous decoction extracts of PO. In this study, fourty male mice (25-30 g) were used in elevated plus maze model. Different doses of the extract. (25,...

Introduction: Effective perception of fear signals is crucial for organism survival. When threated, the organism indicates defensive behaviors. Methods: Elevated plus–maze has high efficiency for measurement of fear behavior and is widly used for fear behavior determination. Increase in two parameters percent of openarm entries (%OAE) and percent of time spent in the open-arm (%OAT) in the ...

Recent studies have shown that glucocorticoids may have modulatory effect on anxiety reactions. This effect may occur with opioid system interference. According to that, the purpose of this research is to assess the effect of dexamethasone as glucocorticoid agonist and its interaction with opioidergic system on the anxiety modulatory effect in plus maze model in mice. Male white mice with mediu...