For applications of block copolymer mixtures as potential new nano-vehicles for delivery, understanding the components mixing characteristics are of special interest. In our previous study [1], we showed that interactions between a biological charged diblock-copolymer like protein, betacasein, and a synthetic uncharged synthetic triblock copolymer, Lutrol F-127, lead to the formation of mixed m...

The temperature-induced structural changes and thermodynamics of ionic microgels based on poly(acrylic acid) (PAA) networks bonded with poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (PEO-PPO-PEO) (Pluronic) copolymers have been studied by small-angle neutron scattering (SANS), ultra-small-angle neutron scattering (USANS), differential scanning calorimetry (DSC), and equili...

Our purpose is to test if Pluronic® fluorescent nanomicelles can be used for in vivo two-photon imaging of both the normal and the tumor vasculature. The nanomicelles were obtained after encapsulating a hydrophobic two-photon dye: di-stryl benzene derivative, in Pluronic block copolymers. Their performance with respect to imaging depth, blood plasma staining, and diffusion across the tumor vasc...

The morphology and stability of small unilamellar egg yolk phosphatidylcholine (EggPC) liposomes modified with the Pluronic copolymer (poly (oxyethylene)-poly (oxypropylene)-poly (oxyethylene) (PEO-PPO-PEO)) with different compositions on mica surface have been investigated using atomic force microscopy. Morphology studies reveal significant morphological changes of liposomes upon incorporating...

Photo-crosslinkable and biodegradable Pluronic/heparin composite hydrogels were fabricated for local and sustained delivery of basic fibroblast growth factor (bFGF) to induce angiogenesis. Terminally di-acrylated Pluronic F127 and vinyl group conjugated heparin were used as a mixed macromer precursor solution to prepare a photo-crosslinkable hydrogel. An aqueous solution containing the two macr...

Методами поляризационной микроскопии и ротационной вискозиметрии изучено влияние хитозана на ориентационно-мицеллярную ассоциацию плюроника F-127 в водной среде диапазоне 4-37 o С. Установлено, что данный амфифильный сополимер претерпевает при повышении температуры фазовый переход формоустойчивый гидрогель, характеризующейся оптическим дихроизмом реограммами вязкости с пределом текучести. Добав...

The self-assembly of amphiphilic (porphyrin)Sn 1 in an aqueous Pluronic F127 media results in the formation of narrowly dispersed nanowires. Variation of aqueous Pluronic concentrations allows for a systematic variation of porphyrin nanowire lengths while keeping their widths constant. These nanowires can be further assembled into secondary macroscopic columns.

mesoporous  mgo  microstructures  were  synthesized  using magnesium  acetate  tetrahydrate,  ammonium  oxalate  monohydrate and  pluronic  f127  via  heating  at  40  °c  for  24  h  and  subsequent calcination. the mesoporous structure of magnesium oxide with the specific  surface  area  of  47m2/g,  pore  volume  0.30  cm3/g  and  the average pore size 24 nm is produced. according to xrd stu...

Objective: This study aimed to develop a topical nanoemulsion using clove oil and ethanol extract of catharanthus roseus (L.) G. for antioxidant antibacterial dosage form. Methods: The was produced spontaneous emulsification method. formulation carried out tween 80 pluronic 127 as surfactants with different concentrations (0.5–2%). characterizations the formula included organoleptic test, homog...

Previously we showed that some excipients can inhibit breast cancer resistance protein (BCRP/ABCG2) in vitro and in vivo. We then evaluated the reversibility and the mode of BCRP inhibition of excipients, such as Tween 20 and Pluronic P85, by the intracellular mitoxantrone uptake study. To evaluate the reversibility of BCRP inhibitory effects, BCRP expressing cells were preincubated with the ex...