We analyze second order parametric processes in a silica microsphere coated with radially aligned nonlinear optical molecules. In a high-Q nonlinear microsphere, we discover that it is possible to achieve ultralow threshold parametric oscillation that obeys the rule of angular momentum conservation. Based on symmetry considerations, one can also implement parametric processes that naturally gen...

cis-dichlorodiammineplatinum(II) (CDDP)-loaded polymeric micelles for cancer therapy have been developed to reduce the serious side effects of cisplatin CDDP. Herein, polymeric micelles incorporated with cisplatin are prepared based on the complexation between CDDP and hydrophilic poly (L-glutamic acid)-b-poly (2-methacryloyloxyethyl phosphorylcholine) (PLG-b-PMPC) diblock copolymers. These CDD...

Transforming growth factor-beta1 (TGF-beta1) is a critical cytokine for cell proliferation and differentiation. It is secreted by many cells in a latent pro-form (LTGF-beta1) from which biologically active TGF-beta1 is released by an in vivo mechanism that is not known. Here we show that the mannose-6-phosphate/insulin-like growth factor II-receptor (M6P/IGFII-R), which binds LTGF-beta1, comple...

We investigate the complexation of ampholytic poly(N-isopropylacylamide)-block-poly- (L-glutamic acid)-block-poly(L-lysine) (PNiPAM-b-PLG-b-PLLys) triblock copolymers and PNiPAM-block-(PLG-co-PLLys) diblock copolymers with counter charged anionic and cationic surfactants. Both triblock and diblock copolymers are able to selectively form complexes through either L-glutamic acid-cationic surfacta...

We demonstrate a low-threshold microsphere laser on a silicon chip, fabricated from erbium-doped silica sol–gel film. Single-longitudinal mode lasing emission is observed from a 37 μm diameter microsphere cavity with an erbium ion concentration of 2× 1019 cm−3. The measured lasing threshold of the silica microsphere laser is as low as 4.8 μW. (Some figures may appear in colour only in the onlin...

The release process of phenol blue from a dibutyrylchitin microsphere, prepared with chitin from a silkworm, into an aqueous solution was kinetically analyzed by single microparticle injection/manipulation and absorption microspectroscopy. The distribution ratio and the release rate of phenol blue in the single microsphere/water system were significantly influenced by the pH of the solution. Th...

In this paper, we have proposed a shell type dielectric microsphere resonator in order to enhance its quality factor. In this work we have assumed that the radius of dielectric microsphere is 12μm and that the interior metal layer radius is 11.5μm. We have obtained analytic equations for Vector potentials, characteristic equation, quality factor, resonance frequency and resonance location of TE...

In this paper we study the special case of Graphic TSP where the underlying graph is a power law graph (PLG). We give a refined analysis of some of the current best approximation algorithms and show that an improved approximation ratio can be achieved for certain ranges of the power law exponent β. For the value of power law exponent β = 1.5 we obtain an approximation ratio of 1.34 for Graphic ...

The quality of graphene intended for use in biosensors was assessed on manufactured chips using a set methods including atomic force microscopy (AFM), Raman spectroscopy, and low-frequency noise investigation. It is shown that local areas residues the surface, formed as result interaction with photoresist at initial stage chip development, led to spread resistance (R) range 1–10 kOhm an increas...