Plantar fasciitis is the most common cause of heel pain and can prove difficult to treat in its most chronic and severe forms. Advanced cases of plantar fasciitis are often associated with ankle stiffness, heel spurs, and other conditions and can lead to extensive physical disability and financial loss. Most available traditional treatments, including orthoses, nonsteroidal anti-inflammatory dr...

Chronic complex musculoskeletal injuries that are slow to heal pose challenges to physicians and researchers alike. Orthobiologics is a relatively newer science that involves application of naturally found materials from biological sources (for example, cell-based therapies), and offers exciting new possibilities to promote and accelerate bone and soft tissue healing. Platelet-rich plasma (PRP)...

http://ajs.sagepub.com/content/early/2016/10/14/0363546516665809 The online version of this article can be found at: DOI: 10.1177/0363546516665809 published online October 17, 2016 Am J Sports Med Brian J. Cole, Vasili Karas, Kristen Hussey, Kyle Pilz and Lisa A. Fortier Osteoarthritis Trial Comparing Clinical Outcomes and Effects on Intra-articular Biology for the Treatment of Knee Hyaluronic ...

OBJECTIVE To evaluate effectiveness of the use of platelet-rich plasma as coadjuvant for union of long bones. METHODS The search strategy included the Cochrane Library (via Central) and MEDLINE (via PubMed). There were no limits as to language or publication media. The latest search strategy was conducted in December 2011. It included randomized clinical trials that evaluated the use of plate...

Platelet-derived Growth Factors (GFs) are biologically active peptides that enhance tissue repair mechanisms such as angiogenesis, extracellular matrix remodeling, and cellular effects as stem cells recruitment, chemotaxis, cell proliferation, and differentiation. Platelet-rich plasma (PRP) is used in a variety of clinical applications, based on the premise that higher GF content should promote...

BACKGROUND Platelet-rich plasma (PRP) has been extensively used as a treatment in tissue healing in tendinopathy, muscle injury, and osteoarthritis. However, there is variation in methods of extraction, and this produces different types of PRP. PURPOSE To determine the composition of PRP obtained from 4 commercial separation kits, which would allow assessment of current classification systems...

1.1 Regenerative periodontal therapy The goal of periodontal therapy is to improve periodontal health and thereby to satisfy the patient’s esthetic and functional needs or demands. To achieve this goal, most periodontal treatments aim to reduce probing depths and maintain or improve attachment levels and these parameters are used as surrogates of improved tooth retention. Conventional periodont...

Platelet concentrates have been gaining popularity for a number of applications in orthopedic surgery as a way to enhance both healing of various tissues and reduce pain. One major area of focus has been the effect of platelet-rich plasma (PRP) on stem cells and chondrocytes and the potential for PRP to enhance cartilage regeneration as well as reduce catabolic factors that lead to cartilage de...

The muscle healing process is defined as a complex and dynamic process resulting in the restoration of anatomic continuity and function. This process is characterized by a cascade of events triggered by the tissue injury itself. It is widely accepted that growth factors play a central role in the healing processes by modulating the recruitment, duplication, activation, and differentiation of di...