patients and methods seventy patients with chronic partial supraspinatus tears in magnetic resonance imaging were randomized into two groups; prp (n = 35) and pt (n = 35). before the treatment, at the end of the treatment and at the 12th month after the end of the treatment, range of motion (rom), visual analog scale (vas) for pain, disabilities of arm, shoulder and hand questionnaire (dash), n...

Strategies to reduce blood loss and transfusion of allogeneic blood products during surgical procedures are important in modern times. The most important and well-known autologous techniques are preoperative autologous predonation, hemodilution, perioperative red cell salvage, postoperative wound blood autotransfusion, and pharmacologic modulation of the hemostatic process. At present, new deve...

The potential influence of leukocyte incorporation in the kinetic release of growth factors from platelet-rich plasma (PRP) may explain the conflicting efficiency of leukocyte platelet-rich plasma (L-PRP) scaffolds in tissue regeneration. To assess this hypothesis, leukocyte-free (PRGF-Endoret) and L-PRP fibrin scaffolds were prepared, and both morphogen and proinflammatory cytokine release kin...

blood transfusion centers are under considerable pressure to produce platelet concentrates with high quality and safety due to the short shelf life of 3-5 days as well as possible bacterial and viral contaminations. for a variety of reasons, many europeans have changed their methods of component production from whole blood using the north american standard platelet-rich plasma method to the buf...

The platelet-rich fibrin (PRF) is known as a rich source of autologous cytokines and growth factors and universally used for tissue regeneration in current clinical medicine. However, the microstructure of PRF has not been fully investigated nor have been studied the key molecules that differ PRF from platelet-rich plasma. We fabricated PRF under Choukroun's protocol and produced its extract (P...

BACKGROUND Protease nexin-1 (PN-1) is a serpin that inhibits plasminogen activators, plasmin, and thrombin. PN-1 is barely detectable in plasma, but we have shown recently that PN-1 is present within the α-granules of platelets. METHODS AND RESULTS In this study, the role of platelet PN-1 in fibrinolysis was investigated with the use of human platelets incubated with a blocking antibody and p...

As meniscal preservation particularly in younger active individuals with a symptomatic meniscal tear remains the preferred treatment option, various methods have been suggested to increase healing and success rates after meniscal repair. The recent increase in clinical use of platelet rich plasma has contributed to the increased use of fibrin clot, which virtually has the same healing property....

Platelet-rich fibrin (PRF) has a lot of benefits in the process healing. The new generation PRF, namely advanced PRF plus (A-PRF+), different structure and more growth factors compared to Advanced (A-PRF), before A-PRF+. Objectives:To effects A-PRF A-PRF+ on IIB degree burn. Methods: This experimental study used 20 male Sprague Dawley rats. All rats were given burn divided into four groups. Gro...