In these times of COVID-19 pandemic, concern has been raised about the potential effects SARS-CoV-2 infection on immunocompromised patients, particularly those receiving B-cell depleting agents and having therefore a severely depressed humoral response. Convalescent plasma can be therapeutic option for patients. Understanding underlying mechanisms convalescent is crucial to optimize such approa...

Abstract Fucoxanthin, a natural xanthophyll carotenoid, is generally found in brown seaweeds, such as Sargassum duplicatum, Turbinaria turbinata, Padina australis, Undaria pinnatifida, and Laminaria japonica; microalga or diatom Phaeodactylum tricornutum, Isochrysis galbana Odontella sinensis. Fucoxanthin marine exhibiting several anticancer activities, activities against leukemia, prostate, ce...

Studies of myeloma cell DNA and immunoglobulin synthesis and total body tumor cell number were performed on a patient with IgE multiple myeloma and plasma cell leukemia; results were contrasted to similar observations in patients with IgG myeloma. Autoradiographic studies demonstrated significantly greater DNA labeling in the IgE patient’s bone marrow plasma cells than in cells from IgG myeloma...

1. Drexler HG. The leukemia-lymphoma cell line facts book. San Diego, CA: Academic Press; 2000. 2. Drexler HG, Matsuo Y, MacLeod RAF. Continuous hematopoietic cell lines as model systems for leukemia-lymphoma research. Leukemia Res. 2000;24:881911. 3. Jernberg-Wiklund H, Nilsson K. Multiple myeloma cell lines. In: Masters JRW, Palsson BO, eds. Human cell culture Vol 3. Cancer cell lines Part 3:...

We have examined the mononuclear cell fraction from 35 individuals, 18 with hematologic malignancies and 17 healthy controls for the presence of cell surface-associated plasminogen activator (PA) activity. PA activity was found on the cell surface of 10 out of 12 samples from patients with acute leukemia. In addition to active urokinase (uPA) found on the cell surface in four out of five acute ...

Meisoindigo has been a routine therapeutic agent in the clinical treatment of chronic myelogenous leukemia (CML) in China since the 1980s. In the present study, the in vitro antileukemic activity of meisoindigo was investigated in acute promyelocytic leukemia (APL) cells, acute myeloid leukemia (AML) cells, and myelomonocytic leukemia cells (NB4, NB4.007/6, HL-60 and U937) comprising both retin...

Session 1 of the 2009 Workshop of the Society for Hematopathology/European Association of Haematopathology, Cleveland, OH, focused on plasma cell neoplasms. This report summarizes the salient diagnostic, clinical, and genetic features of plasma cell myeloma (PCM) and related neoplasms. Based on the cases submitted to the workshop, we highlight common diagnostic issues and unusual manifestations...