Phytochemical analysis of 3 members the Urticaceae family (eg Pilea pumila, Laportea canadensis, and Boehmeria cylindrica) was conducted using GC-MS. P pumila L canadensis have several recorded historical medicinal uses by Native American tribes, whereas B cylindrica does not. This study to understand in terms chemical composition. Plant material, separated into aerial or root portions, dried e...

Objective: analyze and evaluate scientific literature data on the need for use of plant sterols stanols treatment hypercholesterolemia in order to reduce risk coronary heart disease. Materials methods. The article summarizes information publications journals search systems PubMed, Scopus, Google Scholar, as well library databases (eLibrary). Results. Phytosterols (phytosterols), phytostanols, a...

Mutations in either ABCG5 or ABCG8 cause sitosterolemia, an inborn error of metabolism characterized by high plasma plant sterol concentrations. Recently, macrothrombocytopenia was described in a number of sitosterolemia patients, linking hematological dysfunction to disturbed sterol metabolism. Here, we demonstrate that macrothrombocytopenia is an intrinsic feature of murine sitosterolemia. Ab...

Recently we constructed yeast cells that either express the human estrogen receptor alpha or the human androgen receptor in combination with a consensus ERE or ARE repeat in the promoter region of a green fluorescent protein (yEGFP) read-out system. These bioassays were proven to be highly specific for their cognate agonistic compounds. In this study the value of these yeast bioassays was asses...

Plant sterols and stanols are structurally similar to cholesterol and when added to the diet they are able to reduce serum total- and LDL-cholesterol concentrations. They also lower serum triglyceride concentrations in humans, particularly under conditions of hypertriglyceridemia. The aim of this study was to unravel the mechanism by which plant sterols and stanols reduce serum triglyceride con...

The first identification of a sterol in Chlorella was by Klosty and Bergmann (5) in 1952 when they isolated ergosterol from Chlorella pyrenoidosa. More recently, Otsuka (6) identified ergosterol and a A5 sterol in Chlorella ellipsoidea. Ergosterol was the principal component of the mixture. Recent work in this laboratory has been centered about the identification of sterols from other species o...

Host-plant specialization plays a key role in insect evolution, but little is known about its molecular basis. A new paper shows that a cactus-feeding fly became restricted to its host by changes in an enzyme that converts dietary sterols into essential hormones.