BACKGROUND Recent studies have reported conflicting results on the association between selective serotonin reuptake inhibitors (SSRIs) and the risk of heart defects. We aimed to assess the association between SSRIs in pregnant women during the first trimester and the risk of congenital heart defects. METHODS AND RESULTS PubMed and EMBASE up to July 2014 were searched for population-based coho...

Selective serotonin reuptake inhibitors (SSRIs) are utilized in the treatment of depression in pregnant and lactating women. SSRIs may be passed to the fetus through the placenta and the neonate through breastfeeding, potentially exposing them to SSRIs during peri- and postnatal development. However, the long-term effects of this SSRI exposure are still largely unknown. The simplicity and genet...

High doses of antidepressants, particularly clomipramine and selective serotonin reuptake inhibitors (SSRIs), are the well-established treatment for obsessive-compulsive disorder (OCD), but manic/hypomanic episodes potential adverse events associated with this treatment. A systematic literature review was performed on in non-bipolar OCD patients. Clinical, sociodemographic antidepressant charac...

By now, the differential effects of several selective serotonin reuptake inhibitors (SSRIs) on the cytochrome P450 (CYP) enzymes are well defined and that the drug-drug interactions (DDIs) are a major issue in the management of depression. In many cases of DDIs in relation to SSRIs, SSRIs plays as a potent CYP inhibitor. Fluvoxamine has inhibited various CYPs-mediated pathways (especially CYP1A...

Obsessive-compulsive disorder (OCD) is a disabling psychiatric condition affecting 1-2% of the community. Although modern drug, behavioral and psychosurgical therapies have improved the prognosis of OCD considerably, approximately 30% of patients remain treatment-refractory. Currently, selective serotonin (5-HT) reuptake inhibitors (SSRIs) are the drug treatments of choice for OCD. Accordingly,...

Data on the effects of serotonin reuptake inhibitors on learning and memory processes are not consistent. In the present study, the effects of citalopram, a very potent and completely selective inhibitor of the serotonin reuptake on spatial discrimination in the T-maze and Morris water maze, were assessed in mice and/or rats. Animals received different doses of citalopram (1, 2, 4, 8 or 16 mg/k...

Pharmacological management of depressed patients has often relied upon the use of agents that are toxic when taken in large quantities. The recent introduction of selective serotonin reuptake inhibitors (SSRIs) has represented a major advance in the management of depression. While a 'serotonin syndrome' may develop if these drugs are taken in association with other agents, these drugs are belie...

Abstract Background Depression and treatment with antidepressant medication is common in patients malignant glioma. However, the extent to which antidepressants may affect disease not fully understood. Therefore, purpose of present study was investigate possible associations between survival glioma patients. Methods We performed a registry-based cohort including 1231 (WHO grades 2, 3, 4) having...