Elevation of renal interstitial hydrostatic pressure (RIHP) by direct renal interstitial volume expansion increases sodium excretion. This natriuretic response is blunted by the nonspecific inhibition of the cyclooxygenase (COX) enzymes. The present study tested the hypothesis that the natriuretic response to increased RIHP during direct renal interstitial volume expansion is dependent on COX-1...

This paper describes the synthesis and characterization of the copper (II) complex with the non-steroidal anti-inflammatory drug (NSAID) piroxicam. The characterization was performed by elemental analysis, FTIR spectroscopy, X-ray powder diffraction and thermal investigation. The empirical formulae of the complex, [Cu(PX)2(H2O)2]’ . H2O was determined by the mentioned methods, but especially by...

Products of arachidonic acid metabolism are important for mucosal homeostasis, because blockade of this pathway with an NSAID triggers rapid onset of severe colitis in the IL-10 knockout (IL-10(-/-)) model of IBD. Rag mice do not make T or B cells. This study determined whether reconstitution of Rag mice with T cells from IL-10(-/-) mice transferred NSAID colitis susceptibility. Rag mice were r...

New dianionic ionic liquids (ILs) based on carboxylic anions and ammonium cations were prepared characterized. They used as excipients to increase the solubility of two model oral drugs BCS class II, ibuprofen piroxicam. With only 0.2 mol% (≈100 mM) [N4 1 2OH]2[C4H4O4], increases over 40-fold 2-fold for ibuprofen, when compared with parent drug water phosphate buffer solution (PBS) 0.01M pH=7.4...

PURPOSE The purpose of this study was the isolation and structure elucidation of chemical compounds from the rhizomes of Eremostachys laciniata (L) Bunge (EL), an Iranian traditional medicinal herb with a thick root and pale purple or white flowers as well as the clinical studies on the therapeutic efficacy and safety of topical application of the EL extract in the management of some inflammato...

Non-steroidal anti-inflammatory drugs (NSAIDs) have prohypertensive effects and blunt the effects of many antihypertensives. The mechanism of this interaction is still not understood enough. The objective of this investigation was to determine the level of prohypertensive effects of two NSAIDs (ibuprofen, piroxicam) and paracetamol, co-prescribed with two antihypertensive drugs (lisinopril + hy...

PURPOSE A multiparticular floating-pulsatile drug delivery system was developed for time and site specific drug release of piroxicam. A blend of floating and pulsatile principles of drug delivery system would have the advantage that a drug can be released in the upper GI tract after a definite time period. METHODS Hollow microspheres were prepared by the emulsion solvent diffusion method usin...