A catalytic polarographic method for the determination of microgram quantities of Ce(IV) is developed based on the catalytic currents of cerium(IV) in the presence of NH4Cl – NH4OH at pH 6.2 with piperazine. Piperazine produces catalytic current with Ce(IV) at peak potential -0.1 to -0.6 V vs. SCE. The procedure was applied for the estimation of Ce(IV) in water samples. The method is simple, se...

In the title compound, C(38)H(34)Cl(2)N(4)O(2), the piperazine ring adopts a chair conformation. The pyrrolidine rings that are fused to the piperazine ring adopt envelope conformations (in which the C atoms connecting the two rings represent the flap). The indoline ring systems are approximately planar (r.m.s. deviations = 0.026 and 0.034 Å) and are aligned at a dihedral angle of 54.98 (3)°.

In the title compound, C(10)H(16)N(2) (2+)·2HSO(4) (-), the S atoms adopt slightly distorted tetra-hedral geometry and the diprotonated piperazine ring adopts a chair conformation. In the crystal, the 1-phenyl-piperazine-1,4-diium cations are anchored between chains formed by the sulfate entities via inter-molecular bifurcated N-H⋯(O,O) and weak C-H⋯O hydrogen bonds. These hydrogen bonds contri...

Studies are described on the phase I and II metabolism and the toxicological analysis of the piperazine-derived designer drug 1-(3-trifluoromethylphenyl)piperazine (TFMPP) in rat urine using gas chromatography/mass spectrometry (GC/MS) and liquid chromatography/mass spectrometry (LC/MS). The identified metabolites indicated that TFMPP was extensively metabolized, mainly by hydroxylation of the ...

The title compound, C(23)H(23)ClN(2)O(2)S, was synthesized by the nucleophilic substitution of 1-benzhydrylpiperazine with 4-chloro-phenyl-sulfonyl chloride. The piperazine ring is in a chair conformation. The geometry around the S atom is that of a distorted tetra-hedron. There is a large range of bond angles around the piperazine N atoms. The dihedral angle between the least-squares plane (p1...

A series of new 4-(5-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-2-carbonyl)-N-(substituted phenyl)piperazine-1-carboxamides 8(a-e)/carbothioamides 8(f-j) were accomplished for biological interest by the simple addition of active functionalized arylisocyanates 7(a-e)/arylisothiocyanates 7(f-j) with 2-isobutoxy-5-(4-methyl-2-(piperazine-1-carbonyl)thiazol-5-yl)benzonitrile (4). Compound 4 was s...

lead, copper, cobalt, nickel, iron and zinc ions form monocitrate complexes (negative charge) in citrate solution which is absorbed on the citrate form of anion-exchange resins (citrate as counter ion) y exchange of citrate ion with citrate complexes. these are subsequently recovered from the resin by 0.5m ammonium citrate eluent at ph 2.0. under optimized conditions, quantitative recovery was ...

Benzocycloheptapyridine tricyclic compounds with piperazine or substituted piperidine moieties extending either from the 5- or 6-position of the tricyclic bridgehead exhibited enhanced FTase activity: this resulted from favorable binding of the ligand nitrogen with the catalytic zinc found in the FTase. A single isomer at C-11 with piperazine adduct extending from the 6-position, compound 24, e...

In the present work two new analytical methods, a gravimetric and a spectrophotometric, for the assay of piperazine free base and its soluble salts in the anthelmitic preparation "Oxyuran", are described. Both approaches are based on the quantitative reaction between the diprotonated cationic form of piperazine and the 3-methyl-4-nitro-1-p-nitrophenyl-5-pyrazolone (picrolonic acid), in sulfuric...

This paper reports an apparent biological difference between two otherwise identical preparations of piperazine hexahydrate. It reports the cutaneous irritancy and allergenicity ofthis substance and records the effect ofenvironmental temperature on those properties, particularly the former. Finally, it reports severe, delayed asthma-like response to piperazine exposure. Interrogation of compani...