نتایج جستجو برای: piperacillin

تعداد نتایج: 2563  

Journal: :Antimicrobial agents and chemotherapy 1996
T Grebe R Hakenbeck

High-level resistance to beta-lactam antibiotics in Streptococcus pneumoniae is mediated by successive alterations in essential penicillin-binding proteins (PBPs). In the present work, single amino acid changes in S. pneumoniae PBP 2x and PBP 2b that result in reduced affinity for the antibiotic and that confer first-level beta-lactam resistance are defined. Point mutations in the PBP genes wer...

2012
Fahmi Yousef Khan Abdelhaleem Elhiday Imran Fahmi Khudair Hind Yousef Aisha Hussein Omran Samer Hytham Alsamman Maha Elhamid

OBJECTIVES The aim of this study was to evaluate the appropriateness of piperacillin/tazobactam (Tazocin(®); Pfizer, New York, NY) usage in our hospital. SUBJECTS AND METHODS This retrospective study was designed to involve all patients admitted to Hamad General Hospital and prescribed piperacillin/tazobactam as an empiric therapy from January 1 to March 31, 2008. The medical records of such ...

Journal: :Internal medicine 2009
Masafumi Seki Yasuhito Higashiyama Yoshifumi Imamura Shigeki Nakamura Shintaro Kurihara Koichi Izumikawa Hiroshi Kakeya Yoshihiro Yamamoto Katsunori Yanagihara Takayoshi Tashiro Shigeru Kohno

OBJECTIVE To evaluate the clinical usefulness of piperacillin (4 g/day) therapy for community-acquired pneumonia compared to sulbactam/ampicillin (6 g/day). METHODS A randomized prospective clinical study was conducted in patients with mild to severe community-acquired bacterial pneumonia. RESULTS The overall clinical efficiency of piperacillin therapy (4 g/day) in these patients (41/53=77....

Journal: :Diagnostic microbiology and infectious disease 2009
Gita Wasan Patel Nimish Patel Asma Lat Kristen Trombley Sam Enbawe Kelli Manor Raymond Smith Thomas P Lodise

This comparison of intermittent versus extended-infusion piperacillin-tazobactam among patients with Gram-negative infections revealed similar mortality and length of stay. Outcomes remained similar when stratified by MIC value.

Journal: :Tropical Journal of Pharmaceutical Research 2022


 Purpose: To study the pharmacokinetics of piperacillin/tazobactam in renal replacement therapy (CRRT) patients with chronic failure (CRF).
 Methods: Six CRF treated CRRT First Affiliated Hospital Hebei North University from April 2020 to July were selected and administered 4 g piperacillin 0.5 tazobactam within 30 min after, at 5, 30, 45, 60, 90, 120, 180, 240, 360 480 after CRRT. T...

2007

Piperacillin metabolism and biliary excretion are different between humans and preclinical species. In the present study, piperacillin metabolites were characterized in bile and urine of healthy humans and compared with metabolites formed in vitro. Volunteers were administered 2 g of piperacillin IV; blood, urine, and duodenal aspirates (obtained via a custom-made oroenteric catheter) were coll...

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