Recent work by J. Prades and myself on K ! is described. The rst part describes our method to connect in a systematic fashion the short-distance evolution with long-distance matrix-element calculations taking the scheme dependence of the short-distance evolution into account correctly. In the second part I show the results we obtain for the I = 1=2 rule in the chiral limit.

Class-Pi of glutathione s-transferases (GST-Pi) is the specific form of GSTs that are known to participate particularly in the mechanisms of resistance to drugs and carcinogens. This class of the enzyme is referred to as class-P or class-Pi or class π. The accepted terminology in this review article is class-Pi. In this article following a brief description of identified molecular forms of GSTs...

JAM: Facultad de Estudios Superiores-Cuautitlan, UNAM, Coordinacion de Estudios de Posgrado, Apartado Postal 25, Cuautitlan Izcalli, Edo. de Mexico 54700, Mexico. BF, MR: College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66506. HH: College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011. Summary: Eighteen 8-week-old disease-free pigs were infected with A...

Chronic inflammation is a hallmark of HIV infection. Eicosanoids reflect inflammation, oxidant stress, and vascular health and vary by sex and metabolic parameters. Raltegravir (RAL) is an HIV-1 integrase inhibitor that may have limited metabolic effects. We assessed urinary F2-isoprostanes (F2-IsoPs), prostaglandin E2 (PGE-M), prostacyclin (PGI-M), and thromboxane B2 (TxB2) in HIV-infected wom...

Both tomato (Lycopersicon esculentum cv VF 36) plants and suspension cultured cells show phosphate starvation inducible (psi) excretion of acid phosphatase (Apase). Apase excretion in vitro was proportional to the level of exogenous orthophosphate (Pi). Intracellular Apase activity remained the same in both Pi-starved and sufficient cells, while Apase excreted by the starved cells increased by ...

Insulin treatment of Chinese hamster ovary (CHO) cells expressing high levels of the insulin receptor (CHO-IR) was found to markedly activate (10-20-fold) transcription of the luciferase reporter gene (Luc) driven by the serum response element (SRE) of the c-fos promoter. SRE-Luc expression was also strongly activated by co-transfection with expression plasmids encoding for either v-Ras or v-Ra...

Background. An exploratory subanalysis of the ODIN trial was performed to evaluate the efficacy of darunavir/ritonavir (DRV/r) 800/100 mg OD versus 600/100 mg BID in patients who were NNRTI-experienced but PI-naïve. Methods. ODIN was a phase III, 48-week study comparing DRV/r OD versus BID in 590 treatment-experienced patients with no DRV resistance-associated mutations (RAMs) at screening. Pat...

BACKGROUND The PIVOT trial examined whether patients with suppressed viral load on combination antiretroviral therapy could be safely switched long-term to ritonavir-boosted protease inhibitor (PI) monotherapy. The main trial publication reported that only one of 296 patients allocated to PI monotherapy experienced a loss of drug options due to protease mutations (identified by local Sanger seq...

OBJECTIVES To compare the clinical characteristics of Native Hawaiians (NH) and other Pacific Islanders (PI) who are hospitalized with ischemic stroke. DESIGN Retrospective, cross-sectional analysis of medical records. SETTING Tertiary, Primary Stroke Center in Honolulu, Hawaii. PATIENTS Consecutive patients with race/ethnicity identified as NH or PI who were hospitalized for ischemic str...