Five rodent diets have been evaluated for their possible effect on the sexual development of the rat. Groups of 12 pregnant Alpk rats were fed one of the following combinations of diets during pregnancy and postnatally: RM3/RM1, AIN-76A/AIN-76A, RM3/AIN-76A, Teklad Global 2016 (Global)/Global and Purina 5001/Purina 5001. AIN-76A is phytoestrogen-free while the other diets contained varying amou...

A set of isoflavononid and flavonoid analogs was prepared evaluated for estrogen receptor α (ERα) ERβ transactivation anti-neuroinflammatory activities. Structure–activity relationship (SAR) study naturally occurring phytoestrogens, their metabolites, related isoflavone revealed the importance C-ring isoflavonoids ER activity selectivity. Docking suggested putative binding modes daidzein 2 dehy...

Abstract Although studies have shown beneficial effects of the phytoestrogen genistein on reducing ovarian cancer risk, little is known at molecular level regarding how inhibits growth, with estrogen receptor beta (ERb), a hormone-regulated transcription factor, receiving bulk attention. When endogenous and exogenous ligands engage ERb, binds to regulatory regions in genome as enhancers, where ...

The burden of musculoskeletal disease has increased significantly to become the second leading cause YLD (years life with disability). Osteoarthritis (OA) therapy that is often given ibuprofen (NSAID) give side effects. Therefore, it necessary conduct a literature review explore evidence how much potential these materials have for treating OA. was conducted on four databases, e.g., Pubmed, Scop...