نتایج جستجو برای: phytochemical tf

تعداد نتایج: 25325  

Journal: :Blood 2013
Bradley P Sullivan Anna K Kopec Nikita Joshi Holly Cline Juliette A Brown Stephanie C Bishop Karen M Kassel Cheryl Rockwell Nigel Mackman James P Luyendyk

In this study, we characterized tissue factor (TF) expression in mouse hepatocytes (HPCs) and evaluated its role in mouse models of HPC transplantation and acetaminophen (APAP) overdose. TF expression was significantly reduced in isolated HPCs and liver homogenates from TF(flox/flox)/albumin-Cre mice (HPC(ΔTF) mice) compared with TF(flox/flox) mice (control mice). Isolated mouse HPCs expressed ...

Journal: :Blood 1989
C R Chitambar Z Zivkovic

Information regarding transferrin (Tf) receptor degradation is largely incomplete. HL60 cells were shown to release to their growth medium a Tf-binding protein which could be immunoprecipitated by anti-Tf receptor monoclonal antibodies (MoAbs) B3/25 and OKT9. Soluble Tf receptor was detected in the medium within one hour of replating of cells, and its release was inhibited at 4 degrees C. The a...

2016
Joeran Beel Stefan Langer Bela Gipp

TF-IDF is one of the most popular term-weighting schemes, and is applied by search engines, recommender systems, and user modeling engines. With regard to user modeling and recommender systems, we see two shortcomings of TF-IDF. First, calculating IDF requires access to the document corpus from which recommendations are made. Such access is not always given in a user-modeling or recommender sys...

2014
Rama Swamy Nanna

Objective: To investigate the pharmacognostic and preliminary phytochemical characteristics of leaves of an endangered medicinally important forest tree species Strychnos potatorum. Methods: Pharmacognostic and phytochemical investigations were conducted in terms of macroscopic, microscopic, physicochemical and preliminary phytochemical parameters. Results: The macro and microscopic study revea...

Journal: :Blood 2005
Sharlene M Day Jennifer L Reeve Brian Pedersen Diana M Farris Daniel D Myers Michael Im Thomas W Wakefield Nigel Mackman William P Fay

Leukocytes and leukocyte-derived microparticles contain low levels of tissue factor (TF) and incorporate into forming thrombi. Although this circulating pool of TF has been proposed to play a key role in thrombosis, its functional significance relative to that of vascular wall TF is poorly defined. We tested the hypothesis that leukocyte-derived TF contributes to thrombus formation in vivo. Com...

Journal: :Journal of bacteriology 2009
Sylvain Robin Denisio M Togashi Alan G Ryder J Gerard Wall

In eubacteria, trigger factor (TF) is the first chaperone to interact with newly synthesized polypeptides and assist their folding as they emerge from the ribosome. We report the first characterization of a TF from a psychrophilic organism. TF from Psychrobacter frigidicola (TF(Pf)) was cloned, produced in Escherichia coli, and purified. Strikingly, cross-linking and fluorescence anisotropy ana...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2003
Ronnie Tung-Ping Poon Cecilia Pik-Yuk Lau Joanna Wen-Ying Ho Wan-Ching Yu Sheung-Tat Fan John Wong

PURPOSE Recent studies have shown that tissue factor (TF) may be involved in tumor angiogenesis and metastasis. The role of TF in hepatocellular carcinoma (HCC) was unknown. This study evaluated whether TF expression correlates with microvessel density (MVD), vascular endothelial growth factor (VEGF) expression, tumor invasiveness, and prognosis in human HCC. EXPERIMENTAL DESIGN Tissue sample...

Journal: :Advances in pharmacology 2010
Erik W Holy Felix C Tanner

Tissue factor (TF) is the major trigger of the coagulation cascade and thereby crucially involved in the maintenance of vascular hemostasis. By binding factor VIIa, the resulting TF:VIIa complex activates the coagulation factors IX and X ultimately leading to fibrin and clot formation. In the vessel wall, TF expression and activity is detectable in vascular smooth muscle cells and fibroblasts a...

Journal: :Circulation research 2001
R Singh S Pan C S Mueske T Witt L S Kleppe T E Peterson A Slobodova J Y Chang N M Caplice R D Simari

Tissue factor (TF) is a low-molecular-weight glycoprotein that initiates the extrinsic clotting cascade and is considered a major regulator of arterial thrombogenicity. TF pathway inhibitor (TFPI) is a major physiological inhibitor of TF-initiated coagulation. The aim of this study was to define the complex interplay between TF and TFPI and the regulation of vascular thrombogenicity in a model ...

2004
Sharlene M. Day Jennifer L. Reeve Brian Pedersen Diana M Farris Daniel D. Myers Michael Im Thomas W. Wakefield Nigel Mackman William P. Fay

Leukocytes and leukocyte-derived microparticles contain low levels of tissue factor (TF) and incorporate into forming thrombi. Although this circulating pool of TF has been proposed to play a key role in thrombosis, its functional significance relative to that of vascular wall TF is poorly defined. We tested the hypothesis that leukocyte-derived TF contributes to thrombus formation in vivo. Com...

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