For mAbs to be viable therapeutics, they must be formulated to have low viscosity, be chemically stable, and have normal in vivo clearance rates. We explored these properties by observing correlations of up to 60 different antibodies of the IgG1 isotype. Unexpectedly, we observe significant correlations with simple physical properties obtainable from antibody sequences and by molecular dynamics...

Switchable ionic liquids (SWILs) derived from organic bases and alcohols are attractive due to their applications in gas capture, separations, and nanomaterial synthesis. However, their exact solvent structure still remains a mystery. We present the first chemical mapping of a SWIL solvent structure using in situ time-of-flight secondary ion mass spectrometry. In situ chemical mapping discovers...

Etoricoxib, a non-steroidal anti-inflammatory drug, is used to Osteoarthritis, Rheumatoid arthritis and Acute Gouty arthritis. Etoricoxib is practically insoluble in water; hence present study was carried out to enhance dissolution properties of Etoricoxib through the preparation of Solid Dispersions using PEG 6000 as carrier at various proportions by using different techniques like Physical mi...

Solvent properties play a central role in mediating the aggregation and self-assembly of molecular gelators and their growth into fibers. Numerous attempts have been made to correlate the solubility parameters of solvents and gelation abilities of molecular gelators, but a comprehensive comparison of the most important parameters has yet to appear. Here, the degree to which partition coefficien...

The phenomenological permeation coefficients were determined for two artificial cellulose membranes of known thickness and water content. Transport of non-electrolytes was studied with tagged water, urea, glucose, and sucrose. The effect of the unstirred layers on the experimental determination of the coefficients is discussed. Frictional coefficients between membrane matrix and solutes, and be...

Solvent is one of the important components in chemical processes. The type solvent that often used paint and coating industry a hydrocarbon-based which consists diverse complex mixture liquids contains aliphatic, alicyclic aromatic (C5-C8) elements. Aromatic hydrocarbons are environmental pollutants known to be toxic, carcinogenic mutagenic, so with an content less than 1% needed. An appropriat...

We propose a mean-field theory of chemical and physical planar brushes of linear gradient copolymers swollen in a selective solvent. The polymer chains are grafted to the substrate by the ends with the excess of insoluble monomer units, and the majority of the soluble units are located near the free ends of the chains. The grafting points are considered to be immobile (chemical brush) and mobil...

The cellulose paper treated in proportional mixture systems showed higher liquid absorption compare to only EtOH and MeOH treatments. It was approximately 40-70% and 50-91% higher for EtOH-NaOH and MeOH-NaOH treated papers, respectively. All conditions apparently bring about an effect of decreased strength for papers. The lowest tensile strength of 13.0 N/mm was found with EtOH and NaOH treated...

During cellulose dissolution in non-derivatizing solvents, the interand intramolecular hydrogen bonds of the polymer are deconstructed. This occurs either by hydrogen bond formation between one or more components of the solvent systems and the hydroxyl groups of the cellulose or by coordination bond formation between the metal ion present in the medium and the hydroxyl group of cellulose molecu...

There are six tocol analogs present in palm oil, namely α-tocopherol (α-T), α-tocomonoenol (α-T₁), α-tocotrienol (α-T₃), γ-tocotrienol (γ-T₃), β-tocotrioenol (β-T₃) and δ-tocotrienol (δ-T₃). These analogs were difficult to separate chromatographically due to their similar structures, physical and chemical properties. This paper reports on the effect of pressure and injection solvent on the sepa...