To evaluate the usefulness of a combination of linearization and scatter-attenuation correction on 99mTc-bicisate (ECD)-single photon emission tomographic (SPECT) images, both cerebral blood flow (CBF)-positron emission tomographic (PET) images and ECD-SPECT images from fifteen patients with chronic cerebral infarction were acquired. We measured radioactivity counts in regions of interest (ROIs...

BACKGROUND Hybrid imaging combines nuclear medicine imaging such as single photon emission computed tomography (SPECT) or positron emission tomography (PET) with computed tomography (CT). Through this hybrid design, scanned patients accumulate radiation exposure from both applications. Imaging modalities have been the subject of long-term optimization efforts, focusing on diagnostic application...

Conventional radiography produces a single image of an object by measuring the attenuation of an x-ray beam passing through it. When imaging weakly absorbing tissues, x-ray attenuation may be a suboptimal signature of disease-related information. In this paper we describe a new phase-sensitive imaging method, called multiple-image radiography (MIR), which is an improvement on a prior technique ...

Many clinical and research studies in nuclear medicine require quantitation of iodine-123 (123I) distribution for the determination of kinetics or localization. The objective of this study was to implement several reconstruction methods designed for single-photon emission computed tomography (SPECT) using 123I and to evaluate their performance in terms of quantitative accuracy, image artifacts,...

Quantitative imaging of bremsstrahlung from pure beta emitters is proposed as a means for in vivo management of antibody therapy. The method involves the use of high-energy collimation, an empirically selected broad photon energy window to enhance detector sensitivity, and a Wiener restoration filter to compensate for system blur. The measured and filtered data were obtained for an idealized sc...

The treatment couch and some of the positioning devices of patients receiving radiotherapy treatment are made of a material (carbon) which has low attenuation properties for the photon energies used in the radiotherapy. Previous investigations showed the suitability of carbon fiber tabletops in radiotherapy and their very low attenuation properties for a range of X-ray energies and field sizes ...

In order to model photon attenuation and detector resolution variation as a depth-dependent convolution for efficient reconstruction of quantitative SPECT, a central-ray approximation is necessary. This work investigates the impact of the approximation upon reconstruction accuracy and computational efficiency. A patient chest CT image was acquired and converted into an object-specific attenuati...