UNLABELLED We provide a summary of the presentations made at the recent Euro-PDT annual Congress. Presentations covered developments in topical photodynamic therapy (PDT) pertaining to dermatological applications. Recognizing the high prevalence and chronicity of actinic keratosis, one of the approved indications for PDT, there were recommendations to pursue field therapy to treat clinical and ...

Porfimer sodium photodynamic therapy (ps-PDT) for Barrett's esophagus is a powerful endoscopic treatment that can eliminate high-grade dysplasia (HGD) and Barrett's mucosa and reduce the risk of development of cancer in these patients. Ps-PDT typically results in destruction of Barrett's esophagus in the majority of the treated area. However, residual small island of Barrett's mucosa may persis...

In the present study, we evaluated the possibility of enhancing the photodynamic effect of hypericin in transitional cell carcinoma (TCC) spheroids by the use of the oxygen carrier, perfluorodecalin. Following incubation with hypericin, RT-112 TCC spheroids were irradiated in the presence or absence of perfluorodecalin, at light doses of 7 J/cm2 or 28 J/ cm2, delivered at a fluence rate of 15 m...

Inorganic nanoprobes with ultrasmall size have the advantage of kidney clearance, which was very meaningful for achieving clinical application. In this article, Mn2+-doped gold nanoclusters (Mn-AuNCs) were synthesized, by magnetic resonance imaging (MRI) and tumor-microenvironment-responsive chemodynamic therapy (CDT) photodynamic (PDT) achieved. The results showed that...

The treatment and prognosis of cancers the nervous system remain unfavorable to patient, which makes it necessary study alternative therapies as primary or adjuvant treatments existing methods. Photodynamic Therapy (PDT) is a method that consists combining photosensitizer (PS), light source at appropriate wavelength, molecular oxygen, forming reactive oxygen species (ROS), leading death in targ...

Photodynamic therapy (PDT) is a rapidly developing cancer treatment method based on the induction of severe oxidative stress in treated cells. Despite widespread clinical application, molecular mechanisms underlying photodynamic reaction have not yet been fully elucidated. Currently, attention scientific community has drawn to crucial role tumor microenvironment which led transition from using ...

A major challenge in photodynamic therapy (PDT) is the development of new tumor-targeting photosensitizers. The tumor-specific activation is considered to be an effective strategy for designing these photosensitizers. Herein, we describe a novel tumor-pH-responsive supramolecular photosensitizer, LDH-ZnPcS8, which is not photoactive under neutral conditions but is precisely and efficiently acti...

The vertebral column is the most common site of skeletal metastatic development secondary to breast cancer. Multiple clinical treatments are available for spinal metastasis, including systemic bisphosphonates and radiation therapy, however the success of current treatment approaches varies considerably. Alternative treatment strategies for spinal metastatic destruction must be aimed at both red...

A supramolecular nanovehicle (denoted as SNV) was fabricated by encapsulating zinc phthalocyanine (ZnPc) and doxorubicin (DOX) into a copolymer (PVP-b-PAA-g-FA), so as to achieve systematic and synergistic chemotherapy-photodynamic therapy (PDT), targeted tumor imaging and therapy. The sophisticated copolymer designed in this work can load the PDT photosensitizer (ZnPc) and chemotherapy drug (D...