This study evaluated the cytotoxicity of various polybasic acids, poly(alkenoic acid)s, and the monomers with various acidic functional groups such as carboxyl, phosphoryl, and sulfo group. The cell growth of fibroblasts cultivated in medium containing polybasic acids and polymers up to the concentration to 5 mmol/L was not significantly different compared with that of control without their aci...

N substitutions at phosphorus comprise one of the most important classes of reactions in biology. Phosphate diester substitution reactions are catalyzed by nucleases and polymerases and are critical in DNA replication and transcription. Phosphate monoester (phosphoryl transfer) reactions are catalyzed by GTPases, ATPases, protein, and small molecule kinases, protein, and small molecule phosphat...

We quantify the adsorption of organophosphate venomous agent X (VX) on clean and hydroxylated (101) surfaces anatase titanium dioxide (TiO2) with density functional theory (DFT) calculations. Our results show that surface occurs through VX phosphoryl oxygen (OP) site involves formation a Ti···OP dative bond. Steric effects inhibit nitrogen sulfur sites by Ti···N Ti···S bonds. On surface, simila...

The chemical step of Shikimate Kinase Helicobacter pylori, involving the transfer a phosphoryl group, has been studied by using quantum mechanical and molecular (QM/MM) methods. Understanding mechanism this step, present in bacteria other microorganisms but absent humans, can lead to development novel drugs for treatment common diseases caused those pathogenic organisms. Different mechanisms in...

The solution structure of the final phosphoryl transfer complex in the glucose-specific arm of the Escherichia coli phosphotransferase system, between enzyme IIA (IIA) and the cytoplasmic B domain (IIB) of the glucose transporter IICB, has been solved by NMR. The interface ( 1200-Å buried surface) is formed by the interaction of a concave depression on IIA with a convex protrusion on IIB. The p...

The Co(II) complex of a new D 2-symmetric chiral porphyrin 3,5-DiMes-QingPhyrin, [Co(P6)], can catalyze asymmetric aziridination of alkenes with bis(2,2,2-trichloroethyl)phosphoryl azide (TcepN3) as a nitrene source. This new Co(II)-based metalloradical aziridination is suitable for different aromatic olefins, producing the corresponding N-phosphorylaziridines in good to excellent yields (up to...