نتایج جستجو برای: phosphoinositide
تعداد نتایج: 8581 فیلتر نتایج به سال:
The balance between phosphoinositides distributed at specific sites in the plasma membrane causes polarized actin polymerization. Oncogenic transformations affect this by regulating phosphoinositide 3-kinase (PI3K) and phosphatase tensin homolog deleted on chromosome 10 (PTEN), causing metastatic behavior cancer cells. Here, we show that PTEN tumor suppressor gene is required for epithelial cel...
Vascular and lymphatic malformations represent a challenge for clinicians. The identification of inherited somatic mutations in important signaling pathways, including the PI3K (phosphoinositide 3-kinase)/AKT (protein kinase B)/mTOR (mammalian target rapamycin), RAS (rat sarcoma)/RAF (rapidly accelerated fibrosarcoma)/MEK (mitogen-activated protein kinase)/ERK (extracellular signal-regulated ki...
We synthesized the first multifunctionalized phosphoinositide polyphosphate derivatives featuring a photo-removable protecting group (“cage”), photo-crosslinkable diazirine group, and terminal alkyne useful for click chemistry. demonstrate that lipid readily enter cells. After photo-crosslinking, cell fixation fluorescent tagging via chemistry, we determined intracellular location of before aft...
In order to evaluate the role of phosphoinositide turnover in growth factor action, we expressed human Ml muscarinic acetylcholine (Hml) receptors in Chinese hamster lung fibroblasts (CCL39 cell line). In the transfected cells (39Ml-81 clone), but not in wild type fibroblasts, the muscarinic agonist carbachol induced a release of inositol phosphates as strong as (Ythrombin, a very potent growth...
BACKGROUND AND PURPOSE Neuroprotective effects of electric stimulation have been recently shown in ischemic stroke, but the underlying mechanisms remain poorly understood. METHODS Adult Wistar rats weighing 200 to 250 g received occlusion of the right middle cerebral artery for 90 minutes. At 1 hour after reperfusion, electrodes were implanted to rats on the right frontal epidural space. Elec...
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