phosphatidate

The effect of epinephrine on phosphatidate phosphohydrolase (PAP) activity of isolated human hepatocytes was studied. Epineprine inhibited the enzyme activity progressively at concentrations above 0.1 µM, reaching a maximum inhibition of 64.5% at 100 µM concentration. Inclusion of alprenolol, a β-receptor blocker, in the incubation mixture abolished the inhibitory effect of epinephrine on P...

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Phosphorylation of Phosphatidate Phosphatase Regulates Its Membrane Association and Physiological Functions in Saccharomyces cerevisiae

Journal: :Journal of Biological Chemistry 2011

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Phosphatidate and oxidized fatty acids are calcium ionophores. Studies employing arsenazo III in liposomes.

Journal: :Journal of Biological Chemistry 1981

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Increased concentrations of phosphatidate, diacylglycerol and ceramide in ras- and tyrosine kinase (fps)-transformed fibroblasts

Journal: :Oncogene 1997

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Mutation of the TGD1 chloroplast envelope protein affects phosphatidate metabolism in Arabidopsis.

Journal: :The Plant cell 2005

Changcheng Xu Jilian Fan John E Froehlich Koichiro Awai Christoph Benning

Phosphatidate (PA) is a central metabolite of lipid metabolism and a signaling molecule in many eukaryotes, including plants. Mutations in a permease-like protein, TRIGALACTOSYLDIACYLGLYCEROL1 (TGD1), in Arabidopsis thaliana caused the accumulation of triacylglycerols, oligogalactolipids, and PA. Chloroplast lipids were altered in their fatty acid composition consistent with an impairment of li...

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