The pH dependence of acid production and of acid release has been analyzed in cultured gas gland cells of the European eel using a cytosensor microphysiometer. Total acid release of gas gland cells showed an optimum at pH 7.4-7.6, with only a minor reduction at acidic (pH 7.0) as well as at alkaline pH (pH 8.0). The acid production was largely dependent on the availability of extracellular gluc...

When we studied the effects of polyphenols froin apple fruits on melanogenesis in Bl6 mouse melanoma eell lines, phloridzin had dose-dependent progressive effects on melanogenesis between 10 and 500"g/ml without inhibiting cell grewth. At a concentration of 500pg/ml, phloridzin increased the melanin content in the cells to 181Y, of that in control cells. In contrast, phloretin, the aglycon gf p...