نتایج جستجو برای: phenotypic switching
تعداد نتایج: 131871 فیلتر نتایج به سال:
Transmission of cellular identity relies on the faithful transfer of information from the mother to the daughter cell. This process includes accurate replication of the DNA, but also the correct propagation of regulatory programs responsible for cellular identity. Errors in DNA replication (mutations) and protein conformation (prions) can trigger stable phenotypic changes and cause human diseas...
A striking characteristic of cancer cells is their remarkable phenotypic plasticity, which is the ability to switch states or phenotypes in response to environmental fluctuations. Phenotypic changes such as a partial or complete epithelial to mesenchymal transition (EMT) that play important roles in their survival and proliferation, and development of resistance to therapeutic treatments, are w...
Phenotypic transitions play critical roles in host adaptation, virulence, and sexual reproduction in pathogenic fungi. A minority of natural isolates of Candida albicans, which are homozygous at the mating type locus (MTL, a/a or α/α), are known to be able to switch between two distinct cell types: white and opaque. It is puzzling that white-opaque switching has never been observed in the major...
This paper proposes two new soft-switching transformerless converters with high voltage conversion ratio. These proposed converters achieve soft-switching each with a single auxiliary resonant cell. The merit of these converters is reduced switching losses with lesser number of devices. The main switching devices are turned off with zero current switching (ZCS). Apart from the soft-switching fe...
Temperature-sensitive periods were determined by application of temperature shifts and shocks to 3 temperature-sensitive cell division arrest (cda) mutants of Tetrahymena thermophila. A restrictive temperature, 36 degrees C, was found at which all 3 mutants are fully penetrant, yet other physiological effects are minimal. At this temperature, the temperature-sensitive period of cdaC2 is a uniqu...
the direct torque control (dtc) of interior permanent magnet synchronous motor (ipmsm) offers simple structure and fast torque response. the conventional switching table-based dtc (st-dtc) presents some disadvantages like high torque and flux ripple and also variable switching frequency. this paper investigates the improved st-dtc strategies to reduce both torque and flux ripple in dtc of ipmsm...
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