نتایج جستجو برای: phenotype plasticity
تعداد نتایج: 214520 فیلتر نتایج به سال:
Cancer cells within a tumor are functionally heterogeneous and specific subpopulations, defined as cancer initiating cells (CICs), are endowed with higher tumor forming potential. The CIC state, however, is not hierarchically stable and conversion of non-CICs to CICs under microenvironment signals might represent a determinant of tumor aggressiveness. How plasticity is regulated at the cellular...
The ability of high-risk neuroblastoma to survive unfavorable growth conditions and multimodal therapy has produced an elusive childhood cancer with remarkably poor prognosis. A novel phenomenon enabling neuroblastoma to survive selection pressure is its capacity for reversible adaptive plasticity. This plasticity allows cells to transition between highly proliferative anchorage dependent (AD) ...
This is a position paper on phenotype-based evolution modeling. It argues that evolutionary complexity is essentially a functional kind of complexity, and for it to evolve, a full body, or, in other words, a dynamically defined, deeply structured, and plasticity-bound phenotype is required. In approaching this subject, we ask and answer some key questions, which we think are interrelated. The q...
Phenotypic plasticity is the ability of a genotype to express different phenotypes, under different environmental conditions. Behavioral plasticity is a type of phenotypic plasticity in which a change in phenotype can rapidly occur. Though often studied at the level of the population, behavioral plasticity studies at the level of the individual could provide insight into how plasticity evolves ...
One of the new research fields in plasticity is related to choosing a proper non-associated flow rule (NAFR), instead of the associated one (AFR), to predict the experimental results more accurately. The idea of the current research is derived from combining von Mises and Tresca criteria in the places of yield and plastic potential surfaces in rate-independent plasticity. This idea is implemen...
Dysbindin is a schizophrenia susceptibility factor and subunit of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) required for lysosome-related organelle biogenesis, and in neurons, synaptic vesicle assembly, neurotransmission, and plasticity. Protein networks, or interactomes, downstream of dysbindin/BLOC-1 remain partially explored despite their potential to illuminate neurod...
Phenotypic plasticity is important in adaptation and shapes the evolution of organisms. However, we understand little about what aspects of the genome are important in facilitating plasticity. Eusocial insect societies produce plastic phenotypes from the same genome, as reproductives (queens) and nonreproductives (workers). The greatest plasticity is found in the simple eusocial insect societie...
Teleost gill arches are exquisitely evolved to maximize foraging efficiency, and include structures for the capture, filtering, processing of prey. While both plasticity a genetic basis arch traits have been noted, relative contributions genetics environment in shaping these remains poorly understood. East African cichlids particularly useful this line study due their highly diverse plastic fee...
The hypothesis that phenotypic plasticity is maintained by divergent natural selection acting across different environments predicts that populations and species exposed to highly variable environments will express high levels of plasticity. I tested this prediction by measuring the behavioral and morphological responses to aeshnid dragonfly larvae of 16 tadpole species and asking whether preda...
Ocular dominance plasticity (ODP) following monocular deprivation (MD) is a model of activity-dependent neural plasticity that is restricted to an early critical period regulated by maturation of inhibition. Unique developmental plasticity mechanisms may improve outcomes following early brain injury. Our objective was to determine the effects of neonatal cerebral hypoxia-ischemia (HI) on ODP. T...
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