نتایج جستجو برای: phenanthridine

تعداد نتایج: 222  

Journal: :The Journal of biological chemistry 2005
Andreas Vogt Aletheia Tamewitz John Skoko Rachel P Sikorski Kenneth A Giuliano John S Lazo

Mitogen-activated protein kinase phosphatase-1 (MKP-1) is a dual specificity phosphatase that is overexpressed in many human tumors and can protect cells from apoptosis caused by DNA-damaging agents or cellular stress. Small molecule inhibitors of MKP-1 have not been reported, in part because of the lack of structural guidance for inhibitor design and definitive assays for MKP-1 inhibition in i...

2012
Ning Ye Jin-Long Wu

In the title compound, C(31)H(29)ClN(2)O(3), the two heterocyclic rings, belonging to a system of five condensed rings, adopt conformations intermediate between twist-boat and sofa. The secondary amide group is involved in a weak intramolecular N-H⋯N hydrogen bond. In the crystal, molecules are linked by pairs of C-H⋯Cl hydrogen bonds to form inversion dimers. These dimers are linked via a C-H⋯...

2014
John C. Walton

Selective syntheses are now available for compounds of many classes, based on C-centered radicals, exploiting a diverse range of mechanisms. The prospect for chemistry based around N- and O-centered radicals is probably more favorable because of the importance of heterocycles as biologically active materials. Heteroradical chemistry is still comparatively underdeveloped due to the need for safe...

2006
Reiko FUJITA Sota WAKAYANAGI Hideaki WAKAMATSU Hisao MATSUZAKI

heterocycles. Substitution reactions of 1(2H)-isoquinolone derivatives have been reported, however, little attention has been focused on addition reactions. Dyke et al. reported a Diels–Alder (DA) reaction of 2-methyl-1(2H)-isoquinolone derivatives as the diene. To the best of our knowledge, however, there have been no reports of a DA reaction of 1(2H)isoquinolones acting as dienophiles. DA rea...

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