BACKGROUND As direct-to-consumer personal genome testing (DTC-PGT) is increasingly available in Australia, knowledge of Australians' perceptions and attitudes towards this technology is needed in order to assess the (potential) impact it might have on the Australian public and healthcare system. AIMS To explore the knowledge and perceptions of DTC-PGT in an Australian sample. METHODS An onl...

Draft Agreed by Pharmacogenomics Working Party and EWPPK March 2010 Adoption by CHMP for release for consultation 22 April 2010 End of consultation (deadline for comments) 31 October 2010 Agreed by Pharmacogenomics Working Party October 2011 Adoption by CHMP 19 January 2012 Date for coming into effect 1 August 2012 This guideline replaces the Reflection Paper on the use of Pharmacogenetics in t...

• Objective: To review current recommendations for periprocedural anticoagulation management strategies in orthopedic patients and to describe a program utilizing pharmacogenetics in warfarin management of orthopedic surgical patients. • Methods: Review of the literature and descriptive

*These authors contributed equally to this work. Correspondence should be addressed to P. Marquet, INSERM U850, 2 rue du Dr Marcland, 87025 Limoges, France Tel: +33555435895; fax: +33555435936 e-mail: pierre.marquet@unilim.fr Running head: Pharmacogenetics of mycophenolate-induced diarrhea

To determine how genetic variations contribute the variations in drug response, we need to know the genes that are related to drugs of interest. But there are no publicly available data-bases of known gene-drug relationships, and it is time-consuming to search the literature for this information. We have developed a resource to support the storage, summarization, and dissemination of key gene-d...

Pharmacogenetics is the study of genetic basis in the individual response to drugs. A thorough knowledge of this will lead to a future where tailor-made drugs, suiting an individual, can be used. Scandinavian countries have been known for wide usage of pharmacogenetics and the most widely used application is for genotyping CYP2D6 in treating psychiatric illness. The CYP-450 enzyme, a super fami...

Pharmacogenetics is a rapidly developing field, especially in oncology. In the most ideal situation pharmacogenetics will allow oncologists to individualize therapy based on patients' individual germline genetic test results. This can help to improve efficacy, reduce toxicity and predict non-responders in a way that alternative therapy can be chosen or individual dose adjustments can be made. M...

Advances in pharmacogenetic analysis technology have accelerated the movement to incorporate pharmacogenetic analysis data into medicine. Therefore, pharmacists will soon have to provide guidance and raise pharmaceutical questions regarding prescriptions based on patient pharmacogenomic information. The objective of this study was to clarify Japanese pharmacists' awareness of pharmacogenetics. ...

The health care costs associated with prescription drugs are enormous, particularly in patients with polypharmacy (taking more than five prescription medications), and they continue to grow annually. The evolution of pharmacogenetics has provided clinicians with a valuable tool that allows for a smarter, more fine-tuned approach to treating patients for a number of clinical conditions. Applying...

There have been several success stories in the field of pharmacogenetics in recent years, including the analysis of HER2 amplification for trastuzumab selection in breast cancer and VKORC1 genotyping for warfarin dosing in thrombosis. Encouraging results from these studies suggest that genetic factors may indeed be important determinants of drug response and toxicity for at least some drugs. Ho...