The source of ideas and information on medicines most important to journalists in the Netherlands, and most commonly consulted by them, is known to be the scientific medical literature. In this study we therefore, explored the relation between the kind of medicines discussed in the scientific medical literature and those discussed in newspapers. A content analysis of scientific medical journals...

The purpose of this longitudinal study (N = 2,745) was to determine whether adolescents' recent medical use of anxiolytic or sleep medication was associated with increased incidence of using someone else's prescription for these classes of medication (nonmedical use). Data were collected from adolescents attending 5 Detroit area secondary schools between December and April in 3 consecutive acad...

Synthetic approaches to macrosphelide derivatives, based on medicinal chemistry, are summarized. This review contains conventional medicinal chemistry approaches, combinatorial chemistry, fluorous tagging techniques and affinity chromatography preparation. In addition, advances in their apoptosis-inducing activities are also included.

Resveratrol is a polyphenolic flavonoid initially identified as a phytoalexin and as a major constituent of red wine. However interest in this molecule initially developed as a cardioprotective agent and in due course of time therapeutic actions came into limelight. This article explores the different therapeutic activities of Resveratrol and highlights their possible mode of action responsible...

OBJECTIVES One aim of this study was to determine the level of knowledge and understanding of selected individuals about hypertension, as well as their beliefs and perceptions about medicines. The other purpose was to determine the medicines information provision system that these participants were exposed to. METHODS Participants filled in the Beliefs about Medicines questionnaire and one-on...

BACKGROUND The World Health Organization Essential Medicines List (WHO-LIST) and national essential medicines lists differ because many countries face significant challenges, such as product availability, cost, product quality and epidemiological disease profiles. In Brazil, governments pay for drugs that are included on the federal, state and municipal government (REMUME) lists. The extent to ...

The Delhi High Court has rejected the petition filed by Bayer Corporation seeking to stop the Drugs Controller of India (DCGI) from registering a generic version of a patented cancer drug. The case was filed in 2008 by Bayer to try and introduce "patent linkage" which involves linking the registration (marketing approval) of drugs with their patent status. If Bayer's plea for "patent linkage" h...

OBJECTIVE To explore the current use of conventional and complementary medicines in Australians aged ≥ 50 years. DESIGN, SETTING AND PARTICIPANTS Cross-sectional postal survey sent to a random sample of 4500 Australians aged ≥ 50 years between June 2009 and February 2010. MAIN OUTCOME MEASURES Prevalence of medicines use, reasons for medicines use and sources of medicines. RESULTS Respons...

BACKGROUND Generic substitution means that one medicinal product is replaced by another product containing the same active substance. It is strictly regulated with respect to its bioequivalence, and all products must have undergone appropriate studies. Although generic substitution is widely implemented, it still remains to be answered how generic switch influences persistence to long-term trea...

The Medicinal Chemistry Section is part of the Experimental Therapeutics Interdisciplinary Programme that is dedicated to early Drug Discovery activities in the oncology field. Our mission is to discover and to develop new anticancer agents based on novel hypotheses and targets generated by CNIO’s Basic Research Groups, and to do so in close collaboration with these groups. Medicinal chemists a...