The Glanville fritillary butterfly (Melitaea cinxia, Nymphalidae) has a large, well-studied metapopulation in the Aland Islands in Finland. Previous studies have found that the common allozyme genotypes at the phosphoglucose isomerase (PGI) locus are associated with individual variation in performance and fitness, with phenotypic data suggesting ongoing balancing selection via heterozygote adva...

The Personal Globe Inventory (PGI) proposes a unified model of vocational interests, integrating Holland's established interest dimensions, with occupational prestige dimensions. current study evaluates the structural validity PGI short form in Vietnam (N = 1140). results randomized tests hypothetical order relations support inclusion spherical model, as means to better calibrate assessment acr...

J. Rajeswari,1,3 H. Ibach,2,3 C. M. Schneider,1,3 A. T. Costa,4 D. L. R. Santos,4 and D. L. Mills5,* 1Peter Grünberg Institut (PGI-6), Forschungszentrum Jülich, 52425 Jülich, Germany 2Peter Grünberg Institut (PGI-3), Forschungszentrum Jülich, 52425 Jülich, Germany 3Jülich Aachen Research Alliance, Germany 4Instituto de Fı́sica, Universidade Federal Fluminense, 24210-346 Niterói, R. J., Brazil 5D...

The induction of cyclooxygenase is an important event in the pathophysiology of acute lung injury. The purpose of this study was to examine the synergistic effects of various cyclooxygenase products (PGE(2), PGI(2), PGF(2alpha)) on thromboxane A(2) (TxA(2))-mediated pulmonary microvascular dysfunction. The lungs of Sprague-Dawley rats were perfused ex vivo with Krebs-Henseleit buffer containing...

Herein we provide evidence for the coexpression of two distinct prostacyclin (PGI(2)) receptors (IP) on BEAS-2B human airway epithelial cells. IP receptor heterogeneity initially was suggested by the finding that the rank orders of potency of PGI(2) and three structurally similar analogs [taprostene, iloprost, 15-deoxy-16-(m-tolyl)-17,18,19,20-tetranorisocarbacyclin (15-deoxy-TIC)] for the inhi...

A technique for determining pepsinogen group I (PGI) concentrations in endoscopic gastroduodenal biopsies is described and validated. This method has a good precision (intra-assay CVs 4.1% to 8.4%; between-assay CVs 4.6% to 9.3%), and analytical recovery is satisfactory (94% to 102%). Results were uninfluenced by the storage interval of the samples. At PGI-producing sites (i.e., fundus, corpus)...

Developmental biology often yields data in a temporal context. Temporal data in phylogenetic systematics has important uses in the field of evolutionary developmental biology and, in general, comparative biology. The evolution of temporal sequences, specifically developmental sequences, has proven difficult to examine due to the highly variable temporal progression of development. Issues concer...

The initial rates of isomerization between glucose 6-phosphate and fructose Q-phosphate catalyzed by Bacillus stearothermophilus pbospboglucose isomerase (PGI) were measured in both the forward and reverse reactions. Although B. stearothermophilus PGI is a tetrameric enzyme, the reaction rate vs substrate concentration curves for both reactions exhibited Michaelis-Menten kinetic behavior. This ...

Ovarian cancer G-protein-coupled receptor 1 (OGR1) and GPR4 have recently been identified as proton-sensing or extracellular pH-responsive G-protein-coupled receptors stimulating inositol phosphate production and cAMP accumulation, respectively. In the present study, we found that OGR1 and GPR4 mRNAs were expressed in human aortic smooth muscle cells (AoSMCs). Acidic extracellular pH induced in...

A cohort of individuals (n = 136) with lesions as severe as atrophic chronic gastritis (ACG) was cross-sectionally evaluated for the validity assessment of pepsinogen I (PGI) and pepsinogen II (PGII) serum levels for the diagnosis of intestinal metaplasia (IM) and gastric dysplasia. PGI/PGII ratio [median (range)] was 4 (0.5-7.5) in patients with ACG (n = 35); 4.6 (1.9-6.8) in type I IM (n = 18...