Recent studies have reported the ubiquitous distribution of perfluorinated compounds (PFCs), especially perfluorooctanesulfonate (PFOS) and perfluorooctanoic acid (PFOA), in wildlife and human whole blood or serum. In 2003 a solid phase extraction method was developed, which allowed the measurement of PFCs in human breast milk. In the present study, PFCs in samples of human breast milk from 19 ...

BACKGROUND Hypertension is a leading cause of cardiovascular disease worldwide. Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are perfluoroalkyl chemicals (PFCs) used in the manufacture of common consumer products and detected in the blood of the majority of Americans. Emerging biological data suggest that PFC exposure may have a role in the development of hypertension. How...

BACKGROUND Perfluorinated compounds (PFCs) are persistent environmental pollutants. Toxicology studies demonstrate the potential for perfluorooctanoic acid (PFOA) and other PFCs to affect human growth and development. Attention deficit/hyperactivity disorder (ADHD) is a developmental disorder with suspected environmental and genetic etiology. OBJECTIVES We examined the cross-sectional associa...

BACKGROUND Polyfluoroalkyl chemicals (PFCs) are used commonly in commercial applications and are detected in humans and the environment worldwide. Concern has been raised that they may disrupt lipid and weight regulation. OBJECTIVES We investigated the relationship between PFC serum concentrations and lipid and weight outcomes in a large publicly available data set. METHODS We analyzed data...

In order to optimize the solid phase extraction (SPE) conditions of perfluorooctanoic acid (PFOA) in raw leachate and treated leachate, effects activator properties, SPE cartridge, pH value, ionic strength, eluent properties were studied through single factor experiments. The optimal results each obtained. Considering that concentration PFOA is lower than have been further optimized. Based on a...

An ultrasensitive method has been developed for simultaneous determination of perfluorooctane sulfonates (PFOS) and perfluorooctanoic acid (PFOA) in food using an Agilent UHPLC 1290 hyphenated Triple Quadrupole 6460 tandem mass spectrometer. The samples were first extracted using methanol, followed by cleanup with weak anion-exchange cartridge. The resultant solutions were subjected to reversep...

Estimated historical exposures and serum concentrations of perfluorooctanoic acid (PFOA) have been extensively used in epidemiologic studies that examined associations between PFOA exposures and adverse health outcomes among residents in highly exposed areas in the Mid-Ohio Valley. Using measured serum PFOA levels in 2005-2006, we applied two calibration methods to these retrospective exposure ...

This study examined the effect of prenatal perfluorooctanoic acid (PFOA) administration on pre- and postnatal development using peroxisome proliferator-activated receptor α (PPARα)-humanized mice to determine if species differences in receptor activity might influence the developmental effects induced by PFOA. Pregnant mice were treated daily with water or PFOA (3mg/kg) by po gavage from gestat...

This article aims to elucidate on usefulness of vacuum ultraviolet (VUV) for photoreductive degradation of perfluorooctanoic acid (PFOA), a representative perfluorinated compound (PFC), in water for the first time. Bench-scale tests were conducted on oxidative and reductive (with aquated electron: eaq ) mineralization of PFOA using low-pressure UV (LPUV) lamps and potassium iodide. Unlike with ...

An intensive campaign was conducted in September 2012 to collect surface water samples along the tributaries of the Pearl River in southern China. Thirteen perfluoroalkyl acids (PFAAs), including perfluorocarboxylates (PFCAs, C4-C11) and perfluorosulfonates (PFSAs, C4, C6-C8, and C10), were determined using high-performance liquid chromatography/negative electrospray ionization-tandem mass spec...