Fig. 1. Maximum-intensity-projection F-FDG PET image (A), axial non-enhanced CT (B) and fused PET/CT image (C) showing increased tracer uptake corresponding to a 8 cm mass located in the left breast (arrows) with a SUVmax of 22. At hematoxylin and eosin stain the breast mass was composed by large cells arranged into a solid pattern and characterized by abundant vacuolated clear cytoplasm, marke...

Article history: Received 5 August 2016 Accepted 5 August 2016 Available online 9 August 2016 tomography (PET). Brain function, which reflects the amount of ‘activity’ that the brain generates, can be measured via its blood perfusion and/or metabolism by using PET with intravenous injection of a radiopharmaceutical tracer such as H2O (Fox et al., 1984). Active brain regions have a higher need o...

In the context of oncology, dynamic PET imaging coupled with standard graphical linear analysis has been previously employed to enable quantitative estimation of tracer kinetic parameters of physiological interest at the voxel level, thus, enabling quantitative PET parametric imaging. However, dynamic PET acquisition protocols have been confined to the limited axial field-of-view (~15-20 cm) of...

The existence of the cyclotron & PET centre of UJV Rez, a.s., at Masaryk Memorial Cancer Institute allows the Masaryk Memorial Cancer Institute and RECAMO researchers to engage in the research, development and application of new radiopharmaceuticals including compounds labelled by short-living positron emitters (especially [11C]). Currently, a [11C]-labelled tracer, L-[methyl-11C]methionine, is...

BACKGROUND AND PURPOSE (18)F-FDOPA PET demonstrates higher sensitivity and specificity for gliomas than traditional [(18)F] FDG PET imaging. However, PET provides limited anatomic localization. The purpose of this study was to determine whether (18)F-FDOPA PET/MRI fusion can provide precise anatomic localization of abnormal tracer uptake and how this activity corresponds to MR signal abnormalit...

BACKGROUND Choline is a new PET tracer that is useful for the detection of malignant tumor. Choline is a precursor of the biosynthesis of phosphatidylcholine, a major phospholipid in the cell membrane of eukaryotic cells. Malignant tumors have an elevated level of phosphatidylcholine in cell membrane. Thus, choline is a marker of tumor malignancy. METHOD The patient was a 51-year-old man with...

UNLABELLED Integrated whole-body PET/MR facilitates the implementation of a broad variety of respiratory motion correction strategies, taking advantage of the strengths of both modalities. The goal of this study was the quantitative evaluation with clinical data of different MR- and PET-data-based motion correction strategies for integrated PET/MR. METHODS The PET and MR data of 20 patients w...

UNLABELLED This study was designed to compare the value of PET using (11)C-choline with that of PET using (18)F-FDG for the diagnosis of gynecologic tumors. METHODS We examined 21 patients, including 18 patients with untreated primary tumors and 3 patients with suspected recurrence of ovarian cancer. (11)C-choline PET and (18)F-FDG PET were performed within 2 wk of each other on each patient....

In vivo imaging of avb3 expression has important diagnostic and therapeutic applications. Multimeric cyclic RGD peptides are capable of improving the integrin avb3–binding affinity due to the polyvalency effect. Here we report an example of 18F-labeled tetrameric RGD peptide for PET of avb3 expression in both xenograft and spontaneous tumor models. Methods: The tetrameric RGD peptide EfE[c(RGDy...

UNLABELLED This work addresses the issue of using (18)F-FDG PET in patients with renal failure. METHODS A model analysis has been developed to compare tissue (18)F-FDG uptake in a patient who has normal renal function with uptake in a theoretic limiting case that assumes tracer plasma decay is tracer physical decay and is trapped irreversibly. RESULTS This comparison has allowed us to propo...