UNLABELLED Cardiac PET using (18)F-FDG under fasting conditions (fasting (18)F-FDG PET) is a promising technique for identification of cardiac sarcoidosis and assessment of disease activity. The aim of this study was to investigate the usefulness of fasting (18)F-FDG PET in detecting inflammatory lesions of cardiac sarcoidosis from a pathophysiologic standpoint. METHODS Twenty-two patients wi...

Incorporating positron emission tomography (PET) imaging or PET/computed tomographic (PET/CT) imaging into a clinical cardiology practice provides opportunities to better assess patients as well as to expand the services offered by the practice. Clinical evidence continues to accrue, demonstrating the superior quality, the breadth of assessments possible, the diagnostic certainty and accuracy, ...

Dysregulated expression or activation of matrix metalloproteinases (MMPs) is observed in many kinds of live-threatening diseases. Therefore, MMP imaging for example with radiolabelled MMP inhibitors (MMPIs) potentially represents a valuable tool for clinical diagnostics using non-invasive single photon emission computed tomography (SPECT) or positron emission tomography (PET) imaging. This work...

eart diseases are one of the leading cause of death in developed countries, for this reason an early diagnosis of the diseases is absolutely necessary. In order to do so, several tools are used, such as, electrocardiogram (EKG), chest X-Ray (Computed Tomography, CT), blood and stress tests, echocardiogram (ECG), cardiac magnetic resonance (MRI) and nuclear medicine (Single Photon Emission Compu...

OBJECTIVE To gain information on the value of magnetic source imaging (MSI), 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET), and ictal single photon emission computed tomography (SPECT) to predict seizure-free outcome following epilepsy surgery in patients who require intracranial electroencephalography (ICEEG). METHODS This work was part of a prospective observation s...

In this paper, we extend a nonnegatively constrained iterative method and three stopping rules for its iterations to the medical imaging inverse problems of computed tomography (CT), positron emission tomography (PET), and single photon emission computed tomography (SPECT); the iterative method and stopping rules were introduced for use in astronomical imaging. The paper begins with a brief int...

Institute of Neuroscience and Medicine, INM-5: Nuclear Chemistry, Research Centre Jülich, Germany Application of radiolabelled, existing MRI probes using a suitable reporter group for multimodal PET(SPECT)/MRI imaging is limited due to the required alteration of the molecular structure and thus changing their in vivo properties. Radiolabelling of existing MRI contrast agents with PET(SPECT) iso...

The role of COX-2 as a driving force in early tumourigenesis and the current interest in the combination of COX-2 inhibitors with standard therapy in clinical trials creates an urgent need to establish clinically relevant diagnostic tests for COX-2 expression. Molecular imaging using small molecule probes radiolabelled for both PET and SPECT offer the potential to meet this need, providing a mi...

I.-Y. Choi and R. Gruetter (eds.), Neural Metabolism In Vivo, Advances in Neurobiology 4, DOI 10.1007/978-1-4614-1788-0_11, © Springer Science+Business Media, LLC 2012 Abstract Neuroreceptor imaging using PET and SPECT has contributed to clinical neuroscience and diagnosis (e.g. neurodegenerative disease and antipsychotic-drug receptor occupancy). Recent advances in dedicated PET and SPECT inst...

It has been quite some time since a new myocardial perfusion agent for radionuclide imaging was introduced into clinical practice. For more than 30 years, rest and stress myocardial perfusion imaging (MPI), employing first planar and then single photon emission computed tomography (SPECT) technology, have been performed with thallium201, Tc-99m sestamibi and Tc-99m tetrofosmin. MPI with these a...