Gallium-68 a positron emitter radionuclide, with great impact on the nuclear medicine, has been widely used in positron emission tomography (PET) diagnosis of various malignancies in humans during more recent years especially in neuroendocrine tumors (NETs). The vast number of Ge/Ga related generator productions, targeting molecule design (proteins, antibody fragments, affibodies, peptides and ...

Absorbed doses were estimated after intravenous administration of 18F-labeled radiopharmaceuticals in Positron Emission Tomography (PET) studies. These radiopharmaceuticals, [18F]-2-Fluoro-2-Deoxy-D-Glucose (FDG), 6-[18F]Fluoro-L-Dopa (FDOPA) and 18F-5-Fluorodeoxyuridine (FdUR), are used in clinical research at the Cyclotron and Radioisotope Center of Tohoku University. Radiopharmaceutical biok...

During the carcinogenesis process, tumour cells often have a more rapid proliferation potential than cells that participate in blood capillary formation by neoangiogenesis. As a consequence of the poorly organized vasculature of various solid tumours, a limited oxygen delivery is observed. This hypoxic mechanism frequently occurs in solid cancers and can lead to therapeutic resistance. The pres...

Molecular in vivo imaging with the high-resolution and sensitive positron emission tomography (PET) technique requires the preparation of a positron-emitting radiolabeled probe or radiotracer. For this purpose, fluorine-18 is becoming increasingly the radionuclide of choice due to its adequate physical and nuclear characteristics, and also because of the successful use in clinical oncology of 2...

UNLABELLED We have characterized the biodistribution and dosimetry of (18)F-3'-F-6-OH-BTA1 ((18)F-GE067), a newly developed radioligand to visualize and quantify amyloid burden, in healthy elderly human subjects. METHODS Six subjects (5 men and 1 woman; age range, 51-74 y) underwent dynamic whole-body PET/CT for 6 h after a bolus injection of (18)F-GE067. Source organs were delineated on PET/...

90 Y is traditionally considered as a pure β – emitter. However, the decay of this radionuclide has a minor branch to the 0 + first excited state of 90 Zr at 1.76 MeV, that is followed by a β + /β – emission. This internal pair production has been largely studied in the past because it is generated by a rare electric monopole transition (E0) between the states 0 + /0 + of 90 Zr. The positronic ...

Sexuality consists of three aspects that are interrelated and inseparable, biological, physiological and social. The biological aspect considers the individual’s capability to give and to receive pleasure. In consequence, it covers the functionality of the sexual organs and the physiology of human sexual response cycle. Diagnostic imaging modalities, such as single photon emission computed tomo...

Early diagnosis of osteomyelitis and prosthetic bone infection is essential for successful therapy and prevention of complications. Nuclear medicine offers a variety of modalities for this aim, including both single photon emission tomography (SPET) and positron emission tomography (PET) radiopharmaceuticals. The main limitation of these functional images is the fact that they are lacking the s...

Folate receptor ? (FR?) is overexpressed on numerous tumorous cell types such as ovarian or endometrial cancer cells. Moreover, FR? absent from most healthy tissues it normally expressed only the surface of proximal tubules cells kidneys and choroid plexus. Thus, folate-based radiopharmaceuticals have emerged this last two decades a target choice to diagnose treat cancers. Nuclear imaging perfo...

Radiopharmaceuticals are an integral component of nuclear medicine and are widely applied in diagnostics and therapy. Though widely applied, the development of an "ideal" radiopharmaceutical can be challenging. Issues such as specificity, selectivity, sensitivity, and feasible chemistry challenge the design and synthesis of radiopharmaceuticals. Over time, strategies to address the issues have ...