نتایج جستجو برای: peroxisome biogenesis

تعداد نتایج: 36041  

2012
Qi Zhang Yi Wu Hongying Sha Pengyue Zhang Jie Jia Yongshan Hu Jianhong Zhu

Increasing evidence shows that exercise training is neuroprotective after stroke, but the underlying mechanisms are unknown. To clarify this critical issue, the current study investigated the effects of early treadmill exercise on the expression of mitochondrial biogenesis factors. Adult rats were subjected to ischemia induced by middle cerebral artery occlusion followed by reperfusion. Express...

Journal: :FEMS microbiology reviews 2004
Juliette Moyersoen Jungwoo Choe Erkang Fan Wim G J Hol Paul A M Michels

In trypanosomatids (Trypanosoma and Leishmania), protozoa responsible for serious diseases of mankind in tropical and subtropical countries, core carbohydrate metabolism including glycolysis is compartmentalized in peculiar peroxisomes called glycosomes. Proper biogenesis of these organelles and the correct sequestering of glycolytic enzymes are essential to these parasites. Biogenesis of glyco...

Journal: :Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2016

Journal: :The Journal of Cell Biology 1996
G Dodt S J Gould

PEX5 encodes the type-1 peroxisomal targeting signal (PTS1) receptor, one of at least 15 peroxins required for peroxisome biogenesis. Pex5p has a bimodal distribution within the cell, mostly cytosolic with a small amount bound to peroxisomes. This distribution indicates that Pex5p may function as a cycling receptor, a mode of action likely to require interaction with additional peroxins. Loss o...

2017
Mauro A. Rinaldi Wendell A. Fleming Kim L. Gonzalez Jaeseok Park Meredith J. Ventura Ashish B. Patel Bonnie Bartel

A variety of metabolic pathways are sequestered in peroxisomes, conserved organelles that are essential for human and plant survival. Peroxin (PEX) proteins generate and maintain peroxisomes. The PEX1 ATPase facilitates recycling of the peroxisome matrix protein receptor PEX5 and is the most commonly affected peroxin in human peroxisome biogenesis disorders. Here, we describe the isolation and ...

Journal: :Plant physiology 2017
Mauro A Rinaldi Wendell A Fleming Kim L Gonzalez Jaeseok Park Meredith J Ventura Ashish B Patel Bonnie Bartel

A variety of metabolic pathways are sequestered in peroxisomes, conserved organelles that are essential for human and plant survival. Peroxin (PEX) proteins generate and maintain peroxisomes. The PEX1 ATPase facilitates recycling of the peroxisome matrix protein receptor PEX5 and is the most commonly affected peroxin in human peroxisome biogenesis disorders. Here, we describe the isolation and ...

2016
Yasuko Kamisugi Shiro Mitsuya Mahmoud El‐Shami Celia D. Knight Andrew C. Cuming Alison Baker

Peroxisomal biogenesis factor 11 (PEX11) proteins are found in yeasts, mammals and plants, and play a role in peroxisome morphology and regulation of peroxisome division. The moss Physcomitrella patens has six PEX11 isoforms which fall into two subfamilies, similar to those found in monocots and dicots. We carried out targeted gene disruption of the Phypa_PEX11-1 gene and compared the morpholog...

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