Many in-vitro methods for prediction of skin permeability have been reported in literature. Cerasome electrokinetic chromatography is one of the most sophisticated approaches representing a maximum level of similarity to the lipid phase of the stratum corneum. One goal of this study was to investigate the affinity pattern of Cerasome and to compare it with the permeability profile of human skin...

Heterogeneity of permeability is an important factor affecting the production of a carbonate reservoir. How to correctly characterize the heterogeneity of permeability has become a key issue for carbonate reservoir development. In this study, the reservoirs were categorized into four superimposed modes based on the actual logging data from a super-giant heterogeneous carbonate reservoir in the ...

When a mass of saturated clay is heated, as in the case of host soils surrounding nuclear waste disposals at great depth, the thermal expansion of the constituents generates excess pore pressures. The mass of clay is submitted to gradients of pore pressure and temperature, to hydraulic and thermal flows, and to changes in its mechanical properties. In this work, some of these aspects were exper...

Resin injection such as resin transfer molding (RTM) is commonly applied in industry for serial production of composite components. RTM process simulation enables prediction of process parameters that are essential for component and tool design. As for all simulations where material behavior is modeled, validated material properties are indispensable for realistic simulations. Currently, materi...

Optic neuritis is an acute inflammatory condition that is highly associated with multiple sclerosis. Currently, the best predictor of future development of multiple sclerosis is the number of T2 lesions visualized by magnetic resonance imaging. Previous research has found abnormalities in the permeability of the blood-brain barrier in normal-appearing white matter of patients with multiple scle...

Accurate permeability estimation has always been a concern in determining flow units, assigning appropriate capillary pressure andrelative permeability curves to reservoir rock types, geological modeling, and dynamic simulation.Acoustic method can be used as analternative and effective tool for permeability determination. In this study, a four-step approach is proposed for permeability estimati...

To investigate the ultrastructural mechanisms of acute microvessel hyperpermeability by vascular endothelial growth factor (VEGF), we combined a mathematical model (J Biomech Eng 116: 502-513, 1994) with experimental data of the effect of VEGF on microvessel hydraulic conductivity (L(p)) and permeability of various-sized solutes. We examined the effect of VEGF on microvessel permeability to a s...

A prerequisite for successful oral drug therapy is the drug's ability to cross the gastrointestinal barrier. Considering the increasing number of new chemical entities in modern drug discovery, reliable and fast in vitro models are required for early and efficient prediction of intestinal permeability. To mimic the intestinal environment, use of biorelevant media may provide valuable informatio...

[1] Ho, N.F.H., Raub, T.J., Burton, P.S., Barsuhn, C.L., Adson, A., Audus, K.L., Borchardt, R., 2000. Quantitative approaches to delineate passive transport mechanisms in cell culture monolayers. In: Amidon, G.L., Lee, P.I., Topp, E.M. (Eds.). Transport Processes in Pharmaceutical Systems. Marcel Dekker: New York, N.Y., pp. 219-316. [2] Avdeef, A., 2005. The Rise of PAMPA. Expert Opinion Drug M...

Soft computing techniques are recently becoming very popular in the oil industry. A number of computational intelligence-based predictive methods have been widely applied in the industry with high prediction capabilities. Some of the popular methods include feed-forward neural networks, radial basis function network, generalized regression neural network, functional networks, support vector reg...