Peripheral arterial disease (PAD) is stenosis or occlusion of peripheral arterial vessels by atherosclerotic plaque. It may present as intermittent claudication, rest pain and impotence. PAD of the lower limbs is the third most important site of atherosclerotic disease after coronary heart disease and cerebrovascular disease. Increasing age, family history, smoking, hypertension, dyslipidemia a...

CONTINUOUS PEBIDURAL ANAESTHESIA is a useful method of providing pain relief in patients with occlusive peripheral vascular disease and consequent limb gangrene. Although it is not known if the "sympathetic block" thus achieved improves peripheral circulation, a "warm" extremity and relief of pain seem desirable goals. There are a few reports of spinal peridural haemorrhage as a complication of...

Cancer of unknown primary accounts for almost 4-5% of all invasive cancers and consists of tumors from various primary sources with considerable heterogeneity in biology and behaviour. Most of these tumors present with symptoms due to distant metastasis. Histology, immunohistochemistry and molecular profiling is the mainstay for diagnosis. In most cases of adenocarinoma associated with paraneop...

Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy with severe clinical manifestation, frequent recurrence, and poor long-term prognosis. It is usually caused by abnormalities in complement regulation. We report 2 cases of children affected by a catastrophic extrarenal complication. A 4-year-old Indian girl developed gangrene of the finger tips 2 days after initial presen...

Peripheral artery disease (PAD) is characterized by narrowing (stenosis) or occlusion of peripheral arteries with consequent manifestation of ischemic blood flow. In the lower limbs, although asymptomatic in the most cases, PAD may manifest itself in different forms depending on whether it presents as claudication or as critical limb ischemia (CLI). Claudication is a functional manifestation, c...

conclusions the lower levels of sugar in crushed fingers compared to healthy fingers can help to diagnose gangrene in crushed fingers. objectives the current study aimed to compare the blood sugar (bs) levels measured by the glucometer in healthy and crushed fingers to predict gangrene in patients referred to 15 khordad hospital in tehran, iran. methods this cohort study was conducted on 265 pa...

A known case of scleroderma presented with right hemiparesis, focal seizures, optic atrophy and gangrene of digits. There was no evidence of peripheral nerve or muscle involvement. MRI showed multifocal infarcts in both cerebral hemispheres. MR angiography revealed poor flow in bilateral carotid arteries with collateralization from posterior circulation. She improved with phenytoin, nifedipine,...

Peripheral vascular disease as a cause of amputation was first forcefully brought out in Canada by the many cases of acute thromboangiitis obliterans occurring in young men after World War I. In the early days of the 20's, amputation for this disorder was carried out at knee level (Gritti-Stokes), an operation itself considered a daring innovation at the time, the site of election in such cases...