Pulp and Periradicular Pathways 2 Natural Pathways 2 Apical foramen 2 Lateral canals 4 Dentinal tubules 4 Pathological and Iatrogenic Pathways 5 Dental caries 5 Role of microorganisms 6 Root perforations 7 Root perforations during access preparation 7 Root perforations during cleaning and shaping 8 Root perforations during post space preparations 10 Vertical fracture 10 Periradicular Pathosis 1...

Kindler syndrome (KS) is a rare, autosomal recessive genodermatosis characterized by skin blistering and photosensitivity in infancy, progressive poikiloderma, and diffuse cutaneous atrophy. It affects the skin, mucous membranes, and oral cavity and is caused by mutations in the KIND1 gene on 20p12.3. The first case of KS associated with periodontitis was reported in 1996, and have been infrequ...

The impact of smoking on general health has been widely studied and is directly related to several important medical problems including cancer, low birth weight, and pulmonary and cardiovascular disease. In the past 25 years, there has also been an increasing awareness of the role of cigarette consumption in oral health problems such as periodontal disease. Smoking is considered the major risk ...