One of the main challenges cardiovascular tissue engineering is development bioresorbable and compliant small-diameter vascular grafts (SDVG) for patients where autologous are not an option. In this work, electrospun bilayered SDVG based on blends poly(L-lactic acid) (PLLA) segmented polyurethane (PHD) were prepared evaluated. The inner layer these was surface-modified with heparin, following a...

Different software tools for quantification of myocardial perfusion SPECT (MPS) studies are routinely used. Several perfusion parameters can be computed automatically.  Interpretation of the MPS should start with visual inspection of the rotating planar images, visual analysis of reconstructed SPECT slices and then quantitative analysis to confirm the visual impression. Quantification should be...

Conventionally, some bioartificial liver devices are used with separate plasmapheresis unit to separate out plasma from whole blood and adsorbent column to detoxify plasma before it passes through a hepatocytes-laden bioreactor. We aim to develop a hybrid bioreactor that integrates the separate modules in one compact design improving the efficacy of the cryogel based bioreactor as a bioartifici...

In tissue engineering field, it is important to develop a suitable numerical model evaluate scaffold geometry design. The experimental evaluation of the effect each specific parameter on regeneration requires large cost and long time expend. Dynamic cell culture commonly used for generating tissues which could replace damaged tissues. A perfusion bioreactor developed able simulate dynamic cultu...

Acoustic cell filters operate at high separation efficiencies with minimal fouling and have provided a practical alternative for up to 200 L/d perfusion cultures. However, the operation of cell retention systems depends on several settings that should be adjusted depending on the cell concentration and perfusion rate. The impact of operating variables on the separation efficiency performance of...

Increasing worldwide demand for mammalian cell production capacity will likely be partially satisfied by a greater use of higher volumetric productivity perfusion processes. An important additional component of any perfusion system is the cell retention device that can be based on filtration, sedimentation, and/or acoustic technologies. A common concern with these systems is that pumping and tr...