In rabbits which were initially conscious or lightly anaesthetized with pentobarbitone, ketamine respectively increased or did not change arterial pressure, whereas in mechanically ventilated animals there was prolonged depression of both pressure and pregangkioinic sympathetic activity. Although respiratory rate slowed during spontaneous ventilation, blood-gas changes were not responsible for ...

1. Splenic arterial flow and splenic weight were recorded in cats anaesthetized with sodium pentobarbitone. The responses of the spleen to catecholamines, angiotensin and vasopressin were investigated.2. Catecholamines caused responses mediated by alpha- and beta-adrenoceptors in the arteriolar smooth muscle, but only insignificant beta-adrenoceptor responses could be elicited from the capsular...

The dried extracts of aerial parts of Celesia coromandeliane Vahl. (Scrophulariaceae) were evaluated for CNS activities in mice. The methanol extract of aerial part of Celesia coromandeliane (MECC) was found to cause significant depression in general as well as exploratory behavioral profiles in mice. MECC showed reduction in muscle relaxant activity by 30 degrees inclined screen test, as well ...

We have investigated the effects of WY14643, a potent peroxisome proliferator activator receptor-α (PPAR-α) agonist, in a rat model of ligature-induced periodontitis. Male Sprague-Dawley rats were lightly anaesthetized with pentobarbitone (35 mg/kg). Sterile, 2-0 black braided silk thread was placed around the cervix of the lower left first molar and knotted medially. Animals received WY14643 (...

Stimulation of sciatic nerve produced a rise in arterial blood pressure followed by a fall with an increase in the rate and depth of respiration in dogs under pentobarbitone anaesthesia. Application of cotton swabs soaked with GABA in 0.9 % saline to the spinal cord at Ll and L. segments did not change the basal arterial pressure and respiratory rate, but elicited only the pressor effect of sci...

Dimethylformamide (DMF) is widely used as a drug solvent. We found DMF to have wide-spread pharmacological effects including depressant effect on CNS evidenced by a decrease in locomotor activity, body and limb tone and rectal temperature, and potentiation of pentobarbitone sleep. A dose-dependent hypotensive effect was seen in cats and rats. In rats, it was partially blocked by atropine and wa...

Effects of kainic acid lesions in the medullary raphe midline on reflex expirations induced mechanically from the trachea were examined. Spontaneously breathing rabbits were anesthetized by ketamine and xylazine i.m., followed by pentobarbitone i.v. Excitatory neurotoxin kainic acid (2 mg/ml in artificial CSF, total volume of 55-100 nl) was pressure microinjected into the medullary midline, ros...