The enhancer element of hepatitis B virus (HBV) regulates the transcription of all HBV mRNA, including the pregenomic mRNA used during replication. This pregenomic mRNA is transcribed from the core gene promoter which is located 500 bp downstream from the HBV enhancer element. To examine the effect of the HBV enhancer on the activity of the core gene promoter, we constructed various plasmids co...

intraocular area via both corneal and noncorneal pathways which are composed of cornea and conjunctiva–sclera, respectively. Although the corneal pathway is thought to be the primary route of intraocular entry for most drugs, penetration via the noncorneal pathway can also be important for the penetration of drugs which are poorly absorbed across the cornea. In addition, the noncorneal pathway ...

In the past decade, many strategies have been developed to enhance oral drug delivery. Different techniques were investigated, amongst those the use of permeation enhancers such surfactants and biodegradable polymers were studied more extensively. Chitosan and its derivatives have been studied as permeation enhancer. The aim of the current study was to develop a nanoparticulate system based on ...

The shadow enhancer of the short gastrulation (sog) gene directs its sequential expression in the neurogenic ectoderm and the ventral midline of the developing Drosophila embryo. Here, we characterize three unusual features of the shadow enhancer midline activity. First, the minimal regions for the two different enhancer activities exhibit high overlap within the shadow enhancer, meaning that o...

Conventional drilling of rock, in most mining applications, uses the mechanical impact of a metal tool to create the advancing hole. This technique, which has gradually increased in power and thus penetration rate has, however, certain inherent disadvantages. These range from the overall weight of the equipment which must be located at the free face of the hole to the maintenance of alignment o...

In this study, we explore the global effect of the Internet on democracy over the period of 1992 to 2002 by observing the relationships between measures related to democracy and Internet prevalence. Our findings suggest that while Internet usage was not a very powerful predictor of democracy when examining full panel data from 1992 to 2002, it was a stronger predictor when we study data from ju...

The need for a drying stress indicator has previously been stated with some research in the past to this means. Given the recent successes in achieving this goal through monitoring shrinkage, the refinement and further understanding of the process was needed, specifically, the influence that penetration of the mount-foot had on the shrinkage data. Four different LVDTmounts were investigated in ...

Objective(s):Drug delivery through the skin can transfer therapeutic levels of drugs for pharmacological effects. Analgesics such as NSAIDs have gastrointestinal side effects and topical dosage forms of these drugs are mainly preferred, especially for local pains. Meloxicam is one of NSAIDs with no topical form in the market. In this research, we attempted to quantify the skin permeation of a m...